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Adult and Developing Zebrafish as Suitable Models for Cardiac Electrophysiology and Pathology in Research and Industry
(Frontiers Media, 2021-01-13)
The electrophysiological behavior of the zebrafish heart is very similar to that of the human heart. In fact, most of the genes that codify the channels and regulatory proteins required for human cardiac function have their ...
Design and validation of recombinant protein standards for quantitative Western blot analysis of cannabinoid CB1 receptor density in cell membranes: an alternative to radioligand binding methods
(BMC, 2022)
Background: Replacement of radioligand binding assays with antibody-antigen interaction-based approaches for quantitative analysis of G protein-coupled receptor (GPCR) levels requires the use of purified protein standards ...
High Thyrotropin Is Critical for Cardiac Electrical Remodeling and Arrhythmia Vulnerability in Hypothyroidism
(Mary Ann Liebert, 2019-07-17)
Background: Hypothyroidism, the most common endocrine disease, induces cardiac electrical remodeling that creates a substrate for ventricular arrhythmias. Recent studies report that high thyrotropin (TSH) levels are related ...
Kv1.3 Channel Blockade Improves Inflammatory Profile, Reduces Cardiac Electrical Remodeling, and Prevents Arrhythmia in Type 2 Diabetic Rats
(Springer, 2023-02)
Purpose Kv1.3 channel regulates the activity of lymphocytes, macrophages, or adipose tissue and its blockade reduces inflammatory cytokine secretion and improves insulin sensitivity in animals with metabolic syndrome and ...
CaMKII modulates the cardiac transient outward K+ current through their association in non-caveolar membrane rafts
(University of Duisburg-Essen, 2020-01-15)
Background/aims: To test whether the physiological regulation of the cardiac Kv4 channels by the Ca2+/calmodulin-dependent protein kinase II (CaMKII) is restricted to lipid rafts and whether the interactions observed in ...
Deciphering the roles of triiodothyronine (T3) and thyroid stimulating hormone (TSH) on cardiac electrical remodeling in clinical and experimental hypothyroidism
(Springer, 2024-02)
Hypothyroidism is the most frequent endocrine pathology. Although clinical or overt hypothyroidism has been traditionally associated to low T3 / T4 and high thyrotropin (TSH) circulating levels, other forms exist such as ...
Fit-for-purpose based testing and validation of antibodies to amino- and carboxy-terminal domains of cannabinoid receptor 1
(Springer, 2021-11)
Specific and selective anti-CB1 antibodies are among the most powerful research tools to unravel the complex biological processes mediated by the CB1 receptor in both physiological and pathological conditions. However, low ...
Metformin Reduces Potassium Currents and Prolongs Repolarization in Non-Diabetic Heart
(MDPI, 2022-05-27)
Metformin is the first choice drug for the treatment of type 2 diabetes due to positive results in reducing hyperglycaemia and insulin resistance. However, diabetic patients have higher risk of ventricular arrhythmia and ...
Cellular neurochemical characterization and subcellular localization of Phospholipase C-β1 in rat brain
(Elsevier, 2012-10-11)
The present study describes a complete and detailed neuroanatomical distribution map of the phospholipase C beta1 (PLCβ1) isoform along the adult rat neuraxis, and defines the phenotype of cells expressing PLCβ1, along ...
TensioBot: a chatbot assistant for self-managed in-house blood pressure checking
(Springer, 2021-03-15)
[ES] Tensiobot es un chatbot de apoyo asistencial, cuyo objetivo esayudar a los pacientes a realizar sus mediciones de tensión arterial en domicilio. Nuestros resultados muestran que el cumplimiento del programa de control ...