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A Computational Analysis of Protein-Protein Interaction Networks in Neurodegenerative Diseases
(Biomed Central, 2008-06-20)
Background: Recent developments have meant that network theory is making an important contribution to the topological study of biological networks, such as protein-protein interaction (PPI) networks. The identification of ...
Differential Micro RNA Expression in PBMC from Multiple Sclerosis Patients
(Public Library of Science, 2009-07-20)
Differences in gene expression patterns have been documented not only in Multiple Sclerosis patients versus healthy controls but also in the relapse of the disease. Recently a new gene expression modulator has been identified: ...
Prioritization of candidate cancer genes-an aid to oncogenomic studies
(Oxford University Press, 2008-10)
The development of techniques for oncogenomic analyses such as array comparative genomic hybridization, messenger RNA expression arrays and mutational screens have come to the fore in modern cancer research. Studies utilizing ...
A Review of Estimation of Distribution Algorithms in Bioinformatics
(Biomed Central, 2008-09-11)
Evolutionary search algorithms have become an essential asset in the algorithmic toolbox for solving high-dimensional optimization problems in across a broad range of bioinformatics problems. Genetic algorithms, the most ...
Gene Expression Profiling in Limb-Girdle Muscular Dystrophy 2A
(Public Library of Science, 2008-11-18)
Limb-girdle muscular dystrophy type 2A (LGMD2A) is a recessive genetic disorder caused by mutations in calpain 3 (CAPN3). Calpain 3 plays different roles in muscular cells, but little is known about its functions or in ...