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Meta-Analysis of the Embryo Freezing Transfer Interval
(Wiley, 2021-04)
Background The decision of whether frozen embryo transfer (FET) should be performed in the cycle immediately after OPU or at least one cycle later is controversial. FET could improve pregnancy rates in IVF; however, how ...
Associative Conditioning Is a Robust Systemic Behavior in Unicellular Organisms: An Interspecies Comparison
(Frontiers Media, 2021-07-19)
The capacity to learn new efficient systemic behavior is a fundamental issue of contemporary biology. We have recently observed, in a preliminary analysis, the emergence of conditioned behavior in some individual amoebae ...
Estimation of preterm labor immediacy by nonlinear methods
(Public Library Science, 2017-06-01)
Preterm delivery affects about one tenth of human births and is associated with an increased perinatal morbimortality as well as with remarkable costs. Even if there are a number of predictors and markers of preterm delivery, ...
Weighted lambda superstrings applied to vaccine design
(Public Library Science, 2019-02-08)
We generalize the notion of lambda-superstrings, presented in a previous paper, to the notion of weighted lambda-superstrings. This generalization entails an important improvement in the applications to vaccine designs, ...
Self-Organization and Information Processing: from Basic Enzymatic Activities to Complex Adaptive Cellular Behavior
(Frontiers Media, 2021-05-21)
One of the main aims of current biology is to understand the origin of the molecular organization that underlies the complex dynamic architecture of cellular life. Here, we present an overview of the main sources of ...
First computational design using lambda-superstrings and in vivo validation of SARS-CoV-2 vaccine
(Nature Research, 2022-04)
[EN] Coronavirus disease 2019 (COVID-19) is the greatest threat to global health at the present time, and considerable public and private effort is being devoted to fighting this recently emerged disease. Despite the ...
Evidence of conditioned behavior in amoebae
(Nature, 2019-08-15)
Associative memory is the main type of learning by which complex organisms endowed with evolved nervous systems respond efficiently to certain environmental stimuli. It has been found in different multicellular species, ...
Computational and Experimental Evaluation of the Immune Response of Neoantigens for Personalized Vaccine Design
(MDPI, 2023-05-19)
In the last few years, the importance of neoantigens in the development of personalized antitumor vaccines has increased remarkably. In order to study whether bioinformatic tools are effective in detecting neoantigens that ...
A Universal Antigen-Ranking Method to Design Personalized Vaccines Targeting Neoantigens against Melanoma
(MDPI, 2023-01-05)
Background: The main purpose of this article is to introduce a universal mathematics-aided vaccine design method against malignant melanoma based on neoantigens. The universal method can be adapted to the mutanome of each ...
On the Dynamics of the Adenylate Energy System: Homeorhesis vs Homeostasis
(Public Library Science, 2014-10-10)
Biochemical energy is the fundamental element that maintains both the adequate turnover of the biomolecular structures and the functional metabolic viability of unicellular organisms. The levels of ATP, ADP and AMP reflect ...