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Alterations of Oligodendrocyte and Myelin Energy Metabolism in Multiple Sclerosis
(MDPI, 2023-08-18)
Multiple sclerosis (MS) is a complex autoimmune disease of the central nervous system (CNS), characterized by demyelination and neurodegeneration. Oligodendrocytes play a vital role in maintaining the integrity of myelin, ...
Stimulation of synaptic activity promotes TFEB-mediated clearance of pathological MAPT/Tau in cellular and mouse models of tauopathies
(Taylor & Francis, 2023-02)
Synapses represent an important target of Alzheimer disease (AD), and alterations of their excitability are among the earliest changes associated with AD development. Synaptic activation has been shown to be protective in ...
Endocannabinoid signaling in brain diseases: Emerging relevance of glial cells
(Wiley, 2023-01)
The discovery of cannabinoid receptors as the primary molecular targets of psychotropic cannabinoid Delta(9)-tetrahydrocannabinol (Delta(9)-THC) in late 1980s paved the way for investigations on the effects of cannabis-based ...
Microglia and meningeal macrophages depletion delays the onset of experimental autoimmune encephalomyelitis
(SpringerNature, 2023)
In multiple sclerosis and the experimental autoimmune encephalomyelitis (EAE) model, both resident microglia and infiltrating macrophages contribute to demyelination as well as spontaneous remyelination. Nevertheless, the ...