dc.contributor.author | Zabala, Amaia | |
dc.contributor.author | Churruca Ortega, Itziar | |
dc.contributor.author | Macarulla Arenaza, María Teresa | |
dc.contributor.author | Rodríguez Rivera, Víctor Manuel | |
dc.contributor.author | Fernández Quintela, Alfredo | |
dc.contributor.author | Martínez, J. Alfredo | |
dc.contributor.author | Portillo Baquedano, María Puy | |
dc.date.accessioned | 2011-05-20T18:20:52Z | |
dc.date.available | 2011-05-20T18:20:52Z | |
dc.date.issued | 2004-09 | |
dc.identifier.citation | British Journal of Nutrition 92(3) : 383-389 (2004) | es |
dc.identifier.issn | 0007-1145 | |
dc.identifier.uri | http://hdl.handle.net/10810/2570 | |
dc.description.abstract | Conjugated linoleic acid (CLA) refers to the positional and geometric dienoic isomers of linoleic acid. The dietary intake of CLA has been associated with changes in lipid metabolism. The aim of the present work was to assess the effects of the two main isomers of CLA on sterol regulatory element binding protein (SREBP)-1a and SREBP-1c mRNA levels, as well as on mRNA levels and the activities of several lipogenic enzymes in liver. For this purpose hamsters were fed an atherogenic diet supplemented with 5 g linoleic acid, cis-9,trans-11 or trans-10,cis-12 CLA/kg diet for 6 weeks. The trans-10,cis-12 isomer intake produced significantly greater liver weight, but also significantly decreased liver fat accumulation. No changes in mRNA levels of SREBP-1a, SREBP-1c and lipogenic enzymes, or in the activities of these enzymes, were observed. There was no effect of feeding cis-9,trans-11 CLA. These results suggest that increased fat accumulation in liver does not occur on the basis of liver enlargement produced by feeding the trans-10,cis-12 isomer of CLA in hamsters. The reduction in hepatic triacylglycerol content induced by this isomer was not attributable to changes in lipogenesis. | es |
dc.description.sponsorship | Supported by grants from the Ministerio de Ciencia y Tecnología (BFI2002-00273), the Government of the Basque Country (Biogune, Programa Etortek) and University of the País Vasco (00l01.125-E-14788/2002). V. Navarro has a doctoral fellowship from the Spanish Government (Ministerio de Ciencia y Tecnología). | es |
dc.language.iso | eng | es |
dc.publisher | Cambridge University Press | es |
dc.relation | info:eu-repo/grantAgreement/MCYT/BFI2002-00273 | |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | conjugated linoleic acid | es |
dc.subject | lipogenesis | es |
dc.subject | sterol regulatory element binding protein | es |
dc.subject | liver | es |
dc.subject | hamsters | es |
dc.title | The trans-10,cis-12 isomer of conjugated linoleic acid reduces hepatic triacylglycerol content without affecting lipogenic enzymes in hamsters | es |
dc.type | info:eu-repo/semantics/article | es |
dc.rights.holder | Copyright © The Nutrition Society 2004 | es |
dc.relation.publisherversion | http://journals.cambridge.org/abstract_S0007114504001825 | es |
dc.identifier.doi | 10.1079/BJN20041220 | |
dc.departamentoes | Farmacia y ciencias de los alimentos | es_ES |
dc.departamentoeu | Farmazia eta elikagaien zientziak | es_ES |
dc.subject.categoria | MEDICINE | |
dc.subject.categoria | NUTRITION AND DIETETICS | |