Pancreatic Cancer in Lynch Syndrome Patients
dc.contributor.author | Bujanda Fernández de Pierola, Luis | |
dc.contributor.author | Herreros Villanueva, Marta | |
dc.date.accessioned | 2018-03-28T07:55:02Z | |
dc.date.available | 2018-03-28T07:55:02Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Journal of Cancer 8(18) : 3667-3674 (2016) | es_ES |
dc.identifier.issn | 1837-9664 | |
dc.identifier.issn | 10.7150/jca.20750 | |
dc.identifier.uri | http://hdl.handle.net/10810/26027 | |
dc.description.abstract | Although colorectal cancer (CRC) is the most common cancer type in Lynch syndrome (LS) families, patients have also increased lifetime risk of other types of tumors. The accumulated risk of pancreatic cancer (PC) in LS patients is around 3.7% and developed tumors often present a characteristically medullary appearance with prominent lymphocytic infiltration. LS patients are considered in high risk for PC development as they present 8.6-fold increase compared with the general population. Here we review PC cases reported in LS patients and current management guidelines. Literature data show that LS is clearly associated with PC and recent publications also demonstrated a connection with pancreatic neoplasic precursor lesions such as intraductal papillary mucinous neoplasms (IPMN) in these patients. While screening techniques are well established for CRC detection, clear strategies are not yet uniform for PC. Magnetic resonance imaging (MRI) and/or endoscopic ultrasound every 1-2 years in MMR mutation carriers with PC in a first or second-degree relative is recommended. Better pancreatic cancer detection strategies should be urgently defined due to the importance of early diagnosis in this disease. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Ivyspring International Publicactions | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/es/ | * |
dc.subject | colorectal cancer | es_ES |
dc.subject | hereditary | es_ES |
dc.subject | Lynch syndrome | es_ES |
dc.subject | pancreatic cancer | es_ES |
dc.subject | risk | es_ES |
dc.subject | nonpolyposes colorectal-cancer | es_ES |
dc.subject | papillary mucinous neoplasm | es_ES |
dc.subject | mismatch repair gene | es_ES |
dc.subject | society task-force | es_ES |
dc.subject | microsatellite instability | es_ES |
dc.subject | ductal adenocarcinoma | es_ES |
dc.subject | consensus statement | es_ES |
dc.subject | endometrial cancer | es_ES |
dc.subject | increased risk | es_ES |
dc.subject | families | es_ES |
dc.title | Pancreatic Cancer in Lynch Syndrome Patients | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | Ivyspring International Publisher. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions | es_ES |
dc.rights.holder | Atribución-NoComercial 3.0 España | * |
dc.relation.publisherversion | http://www.jcancer.org/v08p3667.htm | es_ES |
dc.departamentoes | Medicina | es_ES |
dc.departamentoeu | Medikuntza | es_ES |
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