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dc.contributor.authorRuiz Larrañaga, Otsanda ORCID
dc.contributor.authorLanga Arranz, Jorge Eliseo ORCID
dc.contributor.authorRendo Fornet, Fernando ORCID
dc.contributor.authorManzano Basabe, Carmen ORCID
dc.contributor.authorIriondo Orensanz, Mikel ORCID
dc.contributor.authorEstomba Recalde, Miren Andone ORCID
dc.date.accessioned2018-07-05T12:21:53Z
dc.date.available2018-07-05T12:21:53Z
dc.date.issued2018-03-22
dc.identifier.citationGenetics Selection Evolution 50 : (2018) // Article ID 9es_ES
dc.identifier.issn0999-193X
dc.identifier.issn1297-9686
dc.identifier.urihttp://hdl.handle.net/10810/27931
dc.description.abstractBackground: The current large spectrum of sheep phenotypic diversity results from the combined product of sheep selection for different production traits such as wool, milk and meat, and its natural adaptation to new environments. In this study, we scanned the genome of 25 Sasi Ardi and 75 Latxa sheep from the Western Pyrenees for three types of regions under selection: (1) regions underlying local adaptation of Sasi Ardi semi-feral sheep, (2) regions related to a long traditional dairy selection pressure in Latxa sheep, and (3) regions experiencing the specific effect of the modern genetic improvement program established for the Latxa breed during the last three decades. Results: Thirty-two selected candidate regions including 147 annotated genes were detected by using three statistical parameters: pooled heterozygosity H, Tajima's D, and Wright's fixation index F-st. For Sasi Ardi sheep, chromosomes Ovis aries (OAR) 4, 6, and 22 showed the strongest signals and harbored several candidate genes related to energy metabolism and morphology (BBS9, ELOVL3 and LDB1), immunity (NFKB2), and reproduction (H2AFZ). The major genomic difference between Sasi Ardi and Latxa sheep was on OAR6, which is known to affect milk production, with highly selected regions around the ABCG2, SPP1, LAP3, NCAPG, LCORL, and MEPE genes in Latxa sheep. The effect of the modern genetic improvement program on Latxa sheep was also evident on OAR15, on which several olfactory genes are located. We also detected several genes involved in reproduction such as ESR1 and ZNF366 that were affected by this selection program. Conclusions: Natural and artificial selection have shaped the genome of both Sasi Ardi and Latxa sheep. Our results suggest that Sasi Ardi traits related to energy metabolism, morphological, reproductive, and immunological features have been under positive selection to adapt this semi-feral sheep to its particular environment. The highly selected Latxa sheep for dairy production showed clear signatures of selection in genomic regions related to milk production. Furthermore, our data indicate that the selection criteria applied in the modern genetic improvement program affect immunity and reproduction traits.es_ES
dc.description.sponsorshipThe authors gratefully acknowledge support from the University of the Basque Country (UPV/EHU) and the Conservatoire des Races d'Aquitaine (US13/29)es_ES
dc.language.isoenges_ES
dc.publisherBiomed Centrales_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectquantitative trait locies_ES
dc.subjectmilk-production traitses_ES
dc.subjectbeef-cattlees_ES
dc.subjectbackcross populationes_ES
dc.subjectnatural-selectiones_ES
dc.subjectfemale fertilityes_ES
dc.subjectcandidate geneses_ES
dc.subjectSLC11A1 genees_ES
dc.subjectassociationes_ES
dc.subjectrevealses_ES
dc.titleGenomic Selection Signatures In Sheep From The Western Pyreneeses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holderThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Attribution 4.0 International (CC BY 4.0) CC0 1.0 Universal (CC0 1.0) Public Domain Dedicationes_ES
dc.rights.holderAtribución 3.0 España*
dc.relation.publisherversionhttps://link.springer.com/article/10.1186/s12711-018-0378-xes_ES
dc.identifier.doi10.1186/s12711-018-0378-x
dc.departamentoesGenética, antropología física y fisiología animales_ES
dc.departamentoeuGenetika,antropologia fisikoa eta animalien fisiologiaes_ES


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This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Attribution 4.0 International (CC BY 4.0) 
CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
Except where otherwise noted, this item's license is described as This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Attribution 4.0 International (CC BY 4.0) CC0 1.0 Universal (CC0 1.0) Public Domain Dedication