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Formulation Of Carbopol((R))/Poly(2-ethyl-2-oxazoline)s Mucoadhesive Tablets For Buccal Delivery Of Hydrocortisone

dc.contributor.authorRuiz Rubio, Leire
dc.contributor.authorAlonso Alonso, María Luz ORCID
dc.contributor.authorPérez Álvarez, Leyre
dc.contributor.authorAlonso Rojas, Rosa María ORCID
dc.contributor.authorVilas Vilela, José Luis ORCID
dc.contributor.authorKhutoryanskiy, Vitaliy V.
dc.date.accessioned2018-07-05T12:28:09Z
dc.date.available2018-07-05T12:28:09Z
dc.date.issued2018-02-11
dc.identifier.citationPolymers 10 : (2018) // Article ID 175es_ES
dc.identifier.issn2073-4360
dc.identifier.urihttp://hdl.handle.net/10810/27932
dc.description.abstractPoly(2-ethyl-2-oxazoline) has become an excellent alternative to the use of poly(ethylene glycol) in pharmaceutical formulations due to its valuable physicochemical and biological properties. This work presents a formulation of poorly-water soluble drug, hydrocortisone, using interpolymer complexes and physical blends of poly(2-ethyl-2-oxazoline)s and two Carbopols (R) (Carbopol 974 and Carbopol 971) for oromucosal administration. The swelling, hydrocortisone release and mucoadhesive properties of a series of tablet formulations obtained by combination of different Carbopols with poly(2-ethyl-2-oxazoline)s of different molecular weights have been evaluated in vitro.es_ES
dc.description.sponsorshipAuthors thank the Basque Country Government for financial support (Ayudas para apoyar las actividades de los grupos de investigacion del sistema universitario vasco, IT718-13 y FRONTIERS (ELKARTEK)).es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectpoly(2-ethyl-2-oxazoline)es_ES
dc.subjectCarbopol((R))es_ES
dc.subjectmucoadhesiones_ES
dc.subjectinterpolymer complexeses_ES
dc.subjectdrug-deliveryes_ES
dc.subjectinterpolymer complexeses_ES
dc.subjectpoly(acrylic acid)es_ES
dc.subjectpoly(ethylene glycol)es_ES
dc.subjecthuman salivaes_ES
dc.subjectsystemses_ES
dc.subjectblendses_ES
dc.subjectmatrixes_ES
dc.subjectalternativeses_ES
dc.subjectdegradationes_ES
dc.titleFormulation Of Carbopol((R))/Poly(2-ethyl-2-oxazoline)s Mucoadhesive Tablets For Buccal Delivery Of Hydrocortisonees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holder© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).es_ES
dc.rights.holderAtribución 3.0 España*
dc.relation.publisherversionhttp://www.mdpi.com/2073-4360/10/2/175es_ES
dc.identifier.doi10.3390/polym10020175
dc.departamentoesQuímica analíticaes_ES
dc.departamentoesQuímica físicaes_ES
dc.departamentoeuKimika analitikoaes_ES
dc.departamentoeuKimika fisikoaes_ES


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© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Except where otherwise noted, this item's license is described as © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).