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Expression Profiling Analysis Reveals Key MicroRNA– mRNA Interactions in Early Retinal Degeneration in Retinitis Pigmentosa

dc.contributor.authorAnasagasti, Ander
dc.contributor.authorEzquerra-Inchausti, Maitane
dc.contributor.authorBarandika, Olatz
dc.contributor.authorMuñoz-Culla, Maider
dc.contributor.authorCaffarel, María M.
dc.contributor.authorOtaegui Bichot, David
dc.contributor.authorLópez de Munain Arregui, Adolfo José
dc.contributor.authorRuiz-Ederra, Javier
dc.date.accessioned2018-11-21T09:09:49Z
dc.date.available2018-11-21T09:09:49Z
dc.date.issued2018-05
dc.identifier.citationInvestigative Ophthalmology & Visual Science 59(6) : 2381-2392 (2018)es_ES
dc.identifier.issn0146-0404
dc.identifier.issn1552-5783
dc.identifier.urihttp://hdl.handle.net/10810/29723
dc.description.abstractPURPOSE. The aim of this study was to identify differentially expressed microRNAs (miRNAs) that might play an important role in the etiology of retinal degeneration in a genetic mouse model of retinitis pigmentosa (rd10 mice) at initial stages of the disease. Methods. miRNAs-mRNA interaction networks were generated for analysis of biological pathways involved in retinal degeneration. RESULTS. Of more than 1900 miRNAs analyzed, we selected 19 miRNAs on the basis of (1) a significant differential expression in rd10 retinas compared with control samples and (2) an inverse expression relationship with predicted mRNA targets involved in biological pathways relevant to retinal biology and/or degeneration. Seven of the selected miRNAs have been associated with retinal dystrophies, whereas, to our knowledge, nine have not been previously linked to any disease. CONCLUSIONS. This study contributes to our understanding of the etiology and progression of retinal degeneration.es_ES
dc.description.sponsorshipSupported by the Fundacion Jesus de Gangoiti Barrera and from the Basque Government's Department of Industry and Education Grants SAIOTEK-PE11BN002, PC12BN001, and DEPLC13/002 (AA, JRE); funds from Foundation of Patients of Retinitis Pigmentosa of Gipuzkoa (Retinosis Gipuzkoa Begisare) (OB); a grant from the Fundacion Mutua Madrilena (OB); Basque Government's Department of Education grants DEDUC14/309 (MEI), Diputacion Foral de Gipuzkoa DFG15/006 (MM-C), and ELKARTEK 16/014 (MM-C); National Institute of Health Carlos III (Instituto de Salud Carlos III) Grants ISCIII: CP10/00572 (JRE), PI13/02621 (JRE); an Intensificacion Contract (ALdM) from the Basque Government's Department of Industry; and a grant from the Foundation of Patients of Retinitis Pigmentosa of Gipuzkoa (Retinosis Gipuzkoa Begisare) (JRE). JR-E is a Miguel Servet II Fellow, National Institute of Health Carlos III (Instituto de Salud Carlos III), ISCIII: CPII16/00012.es_ES
dc.language.isoenges_ES
dc.publisherAssociation Research Vision Ophthalmologyes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectretinitis pigmentosaes_ES
dc.subjectmiRNAes_ES
dc.subjectrd10es_ES
dc.subjectnetwork analysises_ES
dc.subjectmiRNA-mRNA interactiones_ES
dc.subjectrod cgmp phosphodiesterasees_ES
dc.subjectrd10 mousees_ES
dc.subjectdiabetic-retinopathyes_ES
dc.subjecttarget predictiones_ES
dc.subjectgene-expressiones_ES
dc.subjectbinding-siteses_ES
dc.subjectbeta-subunites_ES
dc.subjectapoptosises_ES
dc.subjectcellses_ES
dc.subjectproteines_ES
dc.titleExpression Profiling Analysis Reveals Key MicroRNA– mRNA Interactions in Early Retinal Degeneration in Retinitis Pigmentosaes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holderThis work is licensed under a Creative Commons Attribution 4.0 International License.es_ES
dc.rights.holderAtribución 3.0 España*
dc.relation.publisherversionhttps://iovs.arvojournals.org/article.aspx?articleid=2681208es_ES
dc.identifier.doi10.1167/iovs.18-24091
dc.departamentoesNeurocienciases_ES
dc.departamentoeuNeurozientziakes_ES


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