dc.contributor.author | Díaz Tajada, Esperanza | |
dc.contributor.author | Valle García, María Blanca | |
dc.contributor.author | Ribeiro, Sylvie | |
dc.contributor.author | Lanceros Méndez, Senentxu | |
dc.contributor.author | Barandiarán García, José Manuel | |
dc.date.accessioned | 2018-11-28T14:07:54Z | |
dc.date.available | 2018-11-28T14:07:54Z | |
dc.date.issued | 2018-09 | |
dc.identifier.citation | Nanomaterials 8(9) : (2018) // Article ID 678 | es_ES |
dc.identifier.issn | 2079-4991 | |
dc.identifier.uri | http://hdl.handle.net/10810/29937 | |
dc.description.abstract | This work reports on the synthesis, with the thermally induced phase separation (TIPS) technique, of poly (l-lactide) (PLLA) scaffolds containing Fe-doped hydroxyapatite (FeHA) particles for bone regeneration. Magnetization curves and X-ray diffraction indicate two magnetic particle phases: FeHA and magnetite Fe3O4. Magnetic nanoparticles (MNPs) are approximately 30 +/- 5 nm in width and 125 +/- 25 nm in length, and show typical ferromagnetic properties, including coercivity and rapid saturation magnetization. Scanning electron microscopy (SEM) images of the magnetic scaffolds reveal their complex morphology changes with MNP concentration. Similarly, at compositions of approximately 20% MNPs, the phase separation changes, passing from solid-liquid to liquid-liquid as revealed by the hill-like structures, with low peaks that give the walls in the SEM images a surface pattern of micro-ruggedness typical of nucleation mechanisms and growth. In vitro degradation experiments, carried out for more than 28 weeks, demonstrated that the MNPs delay the scaffold degradation process. Cytotoxicity is appreciated for FeHA content above 20%. | es_ES |
dc.description.sponsorship | This work was supported by the University of The Basque Center and the Portuguese Foundation for Science and Technology (FCT) under the framework Strategic Funding UID/FIS/04650/2013, UID/BIA/04050/2013, and UID/BIO/04469. S.R. would like to the FCT for the SFRH/BD/111478/2015 grant. The authors acknowledge funding by the Spanish Ministry of Economy and Competitiveness (MINECO) under the project MAT2016-76039-C4-3-R (AEI/FEDER, UE) and from the Basque Government Industry Department under the ELKARTEK and HAZITEK programs. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/MAT2016-76039-C4-3-R | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | Fe-doped hydroxyapatite | es_ES |
dc.subject | poly (L-lactide) | es_ES |
dc.subject | scaffolds | es_ES |
dc.subject | magnetism | es_ES |
dc.subject | cytotoxicity tissue engineering applications | es_ES |
dc.subject | phosphate-buffered solution | es_ES |
dc.subject | mechanical-properties | es_ES |
dc.subject | phase-separation | es_ES |
dc.subject | degradation | es_ES |
dc.subject | poly(l-lactide) | es_ES |
dc.subject | hydrolysis | es_ES |
dc.subject | composite | es_ES |
dc.subject | hydroxyapatite | es_ES |
dc.subject | crystallinity | es_ES |
dc.title | Development of Magnetically Active Scaffolds for Bone Regeneration | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0). | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.mdpi.com/2079-4991/8/9/678 | es_ES |
dc.identifier.doi | 10.3390/nano8090678 | |
dc.departamentoes | Electricidad y electrónica | es_ES |
dc.departamentoes | Ingeniería Minera y Metalúrgica y Ciencia de los Materiales | es_ES |
dc.departamentoeu | Elektrizitatea eta elektronika | es_ES |
dc.departamentoeu | Meatze eta metalurgia ingeniaritza materialen zientzia | es_ES |