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Identification of a panel of serum protein markers in early stage of sepsis and its validation in a cohort of patients

dc.contributor.authorGarcia-Obregon, Susana
dc.contributor.authorAzkargorta, Mikel
dc.contributor.authorSeijas, Iratxe
dc.contributor.authorPilar-Orive, Javier
dc.contributor.authorBorrego, Francisco
dc.contributor.authorElortza, Felix
dc.contributor.authorBoyano López, María Dolores ORCID
dc.contributor.authorAstigarraga Aguirre, María Iciar
dc.date.accessioned2018-12-11T11:26:51Z
dc.date.available2018-12-11T11:26:51Z
dc.date.issued2018-08
dc.identifier.citationJournal of Microbiology Immunology and Infection 51(4) : 465-472 (2018)es_ES
dc.identifier.issn1684-1182
dc.identifier.issn1995-9133
dc.identifier.urihttp://hdl.handle.net/10810/30249
dc.description.abstractBackground: Sepsis is a life-threatening illness with a challenging diagnosis. Current serum biomarkers are not sensitive enough for diagnosis. With the aim of finding proteins associated with sepsis, serum protein profile was compared between patients and healthy donors and serum classical inflammatory proteins were analyzed in both groups. Methods: Serum protein profiles were characterized by two-dimensional electrophoresis (2DE). Identification of the proteins was carried out by mass spectrophotometry and their validation was performed by Enzyme-Linked-lmmunoSorbent Assay (ELISA) in a cohort of 85 patients and 67 healthy donors. Seven classical inflammatory proteins were analyzed in the same cohort by ELISA: interleukin-2 receptor alpha-chain (sCD25), scavenger receptor cysteine-es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectELISAes_ES
dc.subjectmass spectrometryes_ES
dc.subjectanalysises_ES
dc.subjectproteomees_ES
dc.subjectsepsises_ES
dc.subjectseptic shockes_ES
dc.subjectserum markerses_ES
dc.subjectinternational consensus definitionses_ES
dc.subjectseptic shock sepsis-3es_ES
dc.subjectdisseminated intravascular coagulationes_ES
dc.subjectlarge gene listses_ES
dc.subjectantithrombin-iiies_ES
dc.subjectclinical-criteriaes_ES
dc.subjectexpressiones_ES
dc.subjectbiomarkerses_ES
dc.subjectmanagementes_ES
dc.subjectproteomicses_ES
dc.titleIdentification of a panel of serum protein markers in early stage of sepsis and its validation in a cohort of patientses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holder2017, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).es_ES
dc.rights.holderAtribución-NoComercial-SinDerivadas (cc by-nc-nd)*
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1684118217300531?via%3Dihubes_ES
dc.identifier.doi10.1016/j.jmii.2016.12.002
dc.departamentoesBiología celular e histologíaes_ES
dc.departamentoesPediatríaes_ES
dc.departamentoeuPediatriaes_ES
dc.departamentoeuZelulen biologia eta histologiaes_ES


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2017, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Except where otherwise noted, this item's license is described as 2017, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).