Genetic affinities among the historical provinces of Romania and Central Europe as revealed by an mtDNA analysis
dc.contributor.author | Cocoş, Relu | |
dc.contributor.author | Schipor, Sorina | |
dc.contributor.author | Hervella Afonso, Montserrat ![]() | |
dc.contributor.author | Cianga, Petru | |
dc.contributor.author | Popescu, Roxana | |
dc.contributor.author | Bănescu, Claudia | |
dc.contributor.author | Constantinescu | |
dc.contributor.author | Martinescu, Alina | |
dc.contributor.author | Raicu, Florina | |
dc.date.accessioned | 2019-04-08T07:52:19Z | |
dc.date.available | 2019-04-08T07:52:19Z | |
dc.date.issued | 2017-03-07 | |
dc.identifier.citation | BMC Genetics 18 : (2017) // Article ID 20 | es_ES |
dc.identifier.issn | 1471-2156 | |
dc.identifier.uri | http://hdl.handle.net/10810/32363 | |
dc.description.abstract | Background: As a major crossroads between Asia and Europe, Romania has experienced continuous migration and invasion episodes. The precise routes may have been shaped by the topology of the territory and had diverse impacts on the genetic structure of mitochondrial DNA (mtDNA) in historical Romanian provinces. We studied 714 Romanians from all historical provinces, Wallachia, Dobrudja, Moldavia, and Transylvania, by analyzing the mtDNA control region and coding markers to encompass the complete landscape of mtDNA haplogroups. Results: We observed a homogenous distribution of the majority of haplogroups among the Romanian provinces and a clear association with the European populations. A principal component analysis and multidimensional scaling analysis supported the genetic similarity of the Wallachia, Moldavia, and Dobrudja groups with the Balkans, while the Transylvania population was closely related to Central European groups. These findings could be explained by the topology of the Romanian territory, where the Carpathian Arch played an important role in migration patterns. Signals of Asian maternal lineages were observed in all Romanian historical provinces, indicating gene flow along the migration routes through East Asia and Europe. Conclusions: Our current findings based on the mtDNA analysis of populations in historical provinces of Romania suggest similarity between populations in Transylvania and Central Europe, supported both by the observed clines in haplogroup frequencies for several European and Asian maternal lineages and MDS analyses. | es_ES |
dc.description.sponsorship | This work was supported by grants two grants of the Romanian National Authority for Scientific Research, CNCS-UEFISCDI, project numbers PN-II-RU-TE-2014-4-0527 and PN-II-ID-PCCE 2011-2-0013; and by the Spanish Ministry of Science and Innovation (GCL2016-79093/P, Basque Government to Research Groups (IT1138-16) and University of the Basque Country-UPV/EHU (UFI 11/09). The funders had no role in the study design, collection, analysis and interpretation of data, or in the writing of the report or decision to submit the article for publication. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Biomed Central | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | mitochondrial DNA | es_ES |
dc.subject | romanian provinces | es_ES |
dc.subject | genetic diversityr | es_ES |
dc.subject | Transylvania | es_ES |
dc.subject | human mitochondrial-DNA | es_ES |
dc.subject | region | es_ES |
dc.subject | sequence | es_ES |
dc.subject | haplogroups | es_ES |
dc.subject | landscape | es_ES |
dc.subject | lineages | es_ES |
dc.subject | genome | es_ES |
dc.title | Genetic affinities among the historical provinces of Romania and Central Europe as revealed by an mtDNA analysis | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://bmcgenet.biomedcentral.com/articles/10.1186/s12863-017-0487-5 | es_ES |
dc.identifier.doi | 10.1186/s12863-017-0487-5 | |
dc.departamentoes | Genética, antropología física y fisiología animal | es_ES |
dc.departamentoeu | Genetika,antropologia fisikoa eta animalien fisiologia | es_ES |
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