dc.contributor.author | Guerrero Azurmendi, Itziar | |
dc.contributor.author | San Segundo Eizaguirre, Marcos | |
dc.contributor.author | Correa Navarro, Arkaitz | |
dc.date.accessioned | 2019-11-15T18:48:30Z | |
dc.date.available | 2019-11-15T18:48:30Z | |
dc.date.issued | 2018-01-22 | |
dc.identifier.citation | Chemical Communications 54(13) : 1627-1630 (2018) | es_ES |
dc.identifier.uri | http://hdl.handle.net/10810/36347 | |
dc.description.abstract | An efficient ligand-free Fe-catalyzed oxidative Ugi-type reaction toward the assembly of α-amino amides and short peptides is described. The reaction proceeds through the α-C(sp3)−H oxidation of N,N-dimethylanilines and further nucleophilic attack of the resulting iminium species by isocyanides. Additive screening showed that judicious choice of the carboxylic acid could lead to the formation of α-amino imides via a 3-component reaction. The process occurs with operational simplicity and is compatible with a variety of sensitive functional groups. | es_ES |
dc.description.sponsorship | We thank for technical and human support provided by Central Service of Analysis de Alava–SGIker of UPV/EHU. We are
grateful to Gobierno Vasco (IT_1033-16) and MINECO (CTQ2016-78395-P) for financial support. A. C. thanksMINECO for a Ramón y Cajal research contract (RYC-2012-09873). Cost-CHAOS action (CA15106) is also acknowledged | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Royal Society of Chemistry | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/CTQ2016-78395-P | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Ugi | es_ES |
dc.subject | iron catalysis | es_ES |
dc.title | Iron-Catalyzed C(sp3)−H Functionalization of N,N-Dimethylanilines with Isocyanides | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | ©The Royal Society of Chemistry 2018 | es_ES |
dc.relation.publisherversion | https://pubs.rsc.org/en/content/articlelanding/2018/CC/C7CC09872C#!divAbstract | es_ES |
dc.departamentoes | Química orgánica I | es_ES |
dc.departamentoeu | Kimika organikoa I | es_ES |