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dc.contributor.authorGómez Zorita, Saioa
dc.contributor.authorAguirre López, Leixuri ORCID
dc.contributor.authorMilton Laskibar, Iñaki
dc.contributor.authorFernández Quintela, Alfredo ORCID
dc.contributor.authorTrepiana Arin, Jenifer ORCID
dc.contributor.authorKajarabille Garcia, Naroa
dc.contributor.authorMosqueda Solís, Andrea
dc.contributor.authorGonzález, Marcela
dc.contributor.authorPortillo Baquedano, María Puy ORCID
dc.date.accessioned2019-12-30T10:06:12Z
dc.date.available2019-12-30T10:06:12Z
dc.date.issued2019-09-19
dc.identifier.citationNutrients 11(9) : (2019) // Article ID 2156es_ES
dc.identifier.issn2072-6643
dc.identifier.urihttp://hdl.handle.net/10810/37411
dc.description.abstractSeveral studies have observed that gut microbiota can play a critical role in nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) development. The gut microbiota is influenced by different environmental factors, which include diet. The aim of the present review is to summarize the information provided in the literature concerning the impact of changes in gut microbiota on the effects which dietary fat has on liver steatosis in rodent models. Most studies in which high-fat feeding has induced steatosis have reported reduced microbiota diversity, regardless of the percentage of energy provided by fat. At the phylum level, an increase in Firmicutes and a reduction in Bacteroidetes is commonly found, although widely diverging results have been described at class, order, family, and genus levels, likely due to differences in experimental design. Unfortunately, this fact makes it difficult to reach clear conclusions concerning the specific microbiota patterns associated with this feeding pattern. With regard to the relationship between high-fat feeding-induced changes in liver and microbiota composition, although several mechanisms such as alteration of gut integrity and increased permeability, inflammation, and metabolite production have been proposed, more scientific evidence is needed to address this issue and thus further studies are needed.es_ES
dc.description.sponsorshipThis research was funded by MINECO (AGL-2015-65719-R-MINECO/FEDER, UE) and Instituto de Salud Carlos III (CIBERobn, CB12/03/30007)es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/AGL-2015-65719-Res_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectdietary fates_ES
dc.subjectsteatosises_ES
dc.subjectgut microbiotaes_ES
dc.subjectdysbiosises_ES
dc.subjectrodentes_ES
dc.subjectliveres_ES
dc.subjectalters gut microbiotaes_ES
dc.subjectintestinal microbiotaes_ES
dc.subjectnonalcoholic steatohepatitises_ES
dc.subjectbile-acidses_ES
dc.subjectmediated attenuationes_ES
dc.subjectinsulin-resistancees_ES
dc.subjecthepatic steatosises_ES
dc.subjectmicees_ES
dc.subjectinflammationes_ES
dc.subjectdiseasees_ES
dc.titleRelationship between Changes in Microbiota and Liver Steatosis Induced by High-Fat Feeding-A Review of Rodent Modelses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holderThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Attribution 4.0 International (CC BY 4.0)es_ES
dc.rights.holderAtribución 3.0 España*
dc.relation.publisherversionhttps://www.mdpi.com/2072-6643/11/9/2156es_ES
dc.identifier.doi10.3390/nu11092156
dc.departamentoesFarmacia y ciencias de los alimentoses_ES
dc.departamentoeuFarmazia eta elikagaien zientziakes_ES


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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Attribution 4.0 International (CC BY 4.0)