dc.contributor.author | Axpe Iza, Eneko | |
dc.contributor.author | Chan, Doreen | |
dc.contributor.author | Offeddu, Giovanni S. | |
dc.contributor.author | Chang, Yin | |
dc.contributor.author | Mérida Sánz, David | |
dc.contributor.author | López Hernández, Héctor | |
dc.contributor.author | Appel, Eric A. | |
dc.date.accessioned | 2020-01-15T08:30:37Z | |
dc.date.available | 2020-01-15T08:30:37Z | |
dc.date.issued | 2019-09-24 | |
dc.identifier.citation | Macromolecules 52(18) : 6889-6897 (2019) | es_ES |
dc.identifier.issn | 0024-9297 | |
dc.identifier.issn | 1520-5835 | |
dc.identifier.uri | http://hdl.handle.net/10810/38466 | |
dc.description.abstract | The number of biomedical applications of hydrogels is increasing rapidly on account of their unique physical, structural, and mechanical properties. The utility of hydrogels as drug delivery systems or tissue engineering scaffolds critically depends on the control of diffusion of solutes through the hydrogel matrix. Predicting or even modeling this diffusion is challenging due to the complex structure of hydrogels. Currently, the diffusivity of solutes in hydrogels is typically modeled by one of three main theories proceeding from distinct diffusion mechanisms: (i) hydrodynamic, (ii) free volume, and (iii) obstruction theory. Yet, a comprehensive predictive model is lacking. Thus, time and capital-intensive trial-and-error procedures are used to test the viability of hydrogel applications. In this work, we have developed a model for the diffusivity of solutes in hydrogels combining the three main theoretical frameworks, which we call the multiscale diffusion model (MSDM). We verified the MSDM by analyzing the diffusivity of dextran of different sizes in a series of poly(ethylene glycol) (PEG) hydrogels with distinct mesh sizes. We measured the subnanoscopic free volume by positron annihilation lifetime spectroscopy (PALS) to characterize the physical hierarchy of these materials. In addition, we performed a meta-analysis of literature data from previous studies on the diffusion of solutes in hydrogels. The model presented outperforms traditional models in predicting solute diffusivity in hydrogels and provides a practical approach to predicting the transport properties of solutes such as drugs through hydrogels used in many biomedical applications. | es_ES |
dc.description.sponsorship | This work was supported by the Center for Human Systems Immunology with Bill & Melinda Gates Foundation (OPP1113682) and a Stanford Bio-X Interdisciplinary Initiatives Program Seed Grant. Dr. Eneko Axpe is thankful for funding support from a postdoctoral fellowship of the Basque Government and for a Marie Sklodowska-Curie Individual Fellowship (INMARE Project No. 796557). Yin Chang acknowledges the Taiwanese Cambridge Trust for her PhD fellowship. Doreen Chan is grateful for an award by the Department of Defense, Air Force Office of Scientific Research, National Defense Science and Engineering Graduate (ND-SEG) Fellowship, 32 CFR 168a, with government support under FA9550-11-C-0028. Authors are very grateful to Prof. Rosanne Zia, Prof. Andrew Spakowitz, and Dr. David Labonte for critical discussions. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Chemical Society | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | poly(ethylene glycol) | es_ES |
dc.subject | drug-delivery | es_ES |
dc.subject | free-volume | es_ES |
dc.subject | transport | es_ES |
dc.subject | water | es_ES |
dc.subject | gels | es_ES |
dc.subject | macromolecules | es_ES |
dc.subject | annihilation | es_ES |
dc.subject | suspensions | es_ES |
dc.subject | membranes | es_ES |
dc.title | A Multiscale Model for Solute Diffusion in Hydrogels | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | This is an open access article published under a Creative Commons Attribution (CC-BY)
License, which permits unrestricted use, distribution and reproduction in any medium,
provided the author and source are cited. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.ncbi.nlm.nih.gov/pubmed?Db=pubmed&Cmd=Retrieve&list_uids=31579160&dopt=abstractplus | es_ES |
dc.identifier.doi | 10.1021/acs.macromol.9b00753 | |
dc.departamentoes | Electricidad y electrónica | es_ES |
dc.departamentoes | Matemática aplicada | es_ES |
dc.departamentoeu | Elektrizitatea eta elektronika | es_ES |
dc.departamentoeu | Matematika aplikatua | es_ES |