dc.contributor.author | Uriel, Clara | |
dc.contributor.author | Sola Llano, Rebeca | |
dc.contributor.author | Bañuelos Prieto, Jorge | |
dc.contributor.author | Gómez López, Ana María | |
dc.contributor.author | López Pérez, José Cristóbal | |
dc.date.accessioned | 2020-02-03T12:43:56Z | |
dc.date.available | 2020-02-03T12:43:56Z | |
dc.date.issued | 2019-06-01 | |
dc.identifier.citation | Molecules 24(11) : (2019) // Article ID 2050 | es_ES |
dc.identifier.issn | 1420-3049 | |
dc.identifier.uri | http://hdl.handle.net/10810/39972 | |
dc.description.abstract | A concise synthetic route from methylmalonate to a tetravalent aliphatic scaffold has been developed. The ensuing tetra-tethered derivative is equipped with two hydroxyl groups, as well as orthogonal alkene and alkyne functionalities. The usefulness of the scaffold has been demonstrated with the preparation of two representative multivalent derivatives: (i) a tetravalent compound containing two D-mannose units, one fluorescent boron-dipyrromethene (BODIPY) dye and a suitably functionalized amino acid and (ii) by way of dimerization and saponification, a water-soluble tetramannan derivative containing two fluorescent BODIPY units. Additionally, photophysical measurements conducted on these derivatives support the viability of the herein designed single and double BODIPY-labeled carbohydrate-based clusters as fluorescent markers. | es_ES |
dc.description.sponsorship | This research was funded by Ministerio de Economia y Competitividad (MINECO) CTQ2015-66702-R, MINECO (MAT2017-83856-C3-3-P), Ministerio de Ciencia Innovacion y Universidades RTI2018-094862-B-I00, and Gobierno Vasco (IT912-16) | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/CTQ2015-66702-R | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/MAT2017-83856-C3-3-P | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | tetravalent scaffold | es_ES |
dc.subject | BODIPY | es_ES |
dc.subject | conjugation | es_ES |
dc.subject | glycosylation | es_ES |
dc.subject | monosaccharide | es_ES |
dc.subject | multivalent presentation | es_ES |
dc.title | A Malonyl-Based Scaffold for Conjugatable Multivalent Carbohydrate-BODIPY Presentations | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0) | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.mdpi.com/1420-3049/24/11/2050 | es_ES |
dc.identifier.doi | 10.3390/molecules24112050 | |
dc.departamentoes | Química física | es_ES |
dc.departamentoeu | Kimika fisikoa | es_ES |