dc.contributor.author | Mico, Juan Antonio | |
dc.contributor.author | Rojas Corrales, Maria Olga | |
dc.contributor.author | Gibert Rahola, Juan | |
dc.contributor.author | Parellada, Mara | |
dc.contributor.author | Moreno, Dolores | |
dc.contributor.author | Fraguas, David | |
dc.contributor.author | Graell Berna, Montserrat | |
dc.contributor.author | Gil Goicouría, Francisco Javier | |
dc.contributor.author | Irazusta Astiazaran, Jon | |
dc.contributor.author | Castro Fornieles, Josefina | |
dc.contributor.author | Soutullo, César | |
dc.contributor.author | Arango, Celso | |
dc.contributor.author | Otero, Soraya | |
dc.contributor.author | Navarro, Ana | |
dc.contributor.author | Baeza, Inmaculada | |
dc.contributor.author | Martínez Cengotitabengoa, Mónica | |
dc.contributor.author | González Pinto Arrillaga, Ana María | |
dc.date.accessioned | 2011-06-10T10:45:42Z | |
dc.date.available | 2011-06-10T10:45:42Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | BMC Psychiatry 11(26) : (2011) | es |
dc.identifier.issn | 1471-244X | |
dc.identifier.uri | http://hdl.handle.net/10810/4180 | |
dc.description.abstract | Background
Our objective is to determine the activity of the antioxidant defense system at admission in patients with early onset first psychotic episodes compared with a control group.
Methods
Total antioxidant status (TAS) and lipid peroxidation (LOOH) were determined in plasma. Enzyme activities and total glutathione levels were determined in erythrocytes in 102 children and adolescents with a first psychotic episode and 98 healthy controls.
Results
A decrease in antioxidant defense was found in patients, measured as decreased TAS and glutathione levels. Lipid damage (LOOH) and glutathione peroxidase activity was higher in patients than controls. Our study shows a decrease in the antioxidant defense system in early onset first episode psychotic patients.
Conclusions
Glutathione deficit seems to be implicated in psychosis, and may be an important indirect biomarker of oxidative stress in early-onset schizophrenia. Oxidative damage is present in these patients, and may contribute to its pathophysiology. | es |
dc.description.sponsorship | Gobierno de España | es |
dc.language.iso | eng | es |
dc.publisher | BioMed Cental | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | developmental infantile psychosis | es |
dc.subject | age children presents | es |
dc.subject | K sads PL | es |
dc.subject | oxidative stress | es |
dc.subject | superoxidative dismusate | es |
dc.subject | glutathione deficit | es |
dc.subject | affective dissorders | es |
dc.subject | lipid peroxidation | es |
dc.subject | bipolar disorder | es |
dc.subject | atypical antipsychotic | es |
dc.title | Reduced antioxidant defense in early onset first-episode psychosis: a case-control study | es |
dc.type | info:eu-repo/semantics/article | es |
dc.rights.holder | © 2011 Micó et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons
Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in
any medium, provided the original work is properly cited. | es |
dc.relation.publisherversion | http://www.biomedcentral.com/1471-244X/11/26 | es |
dc.identifier.doi | 10.1186/1471-244X-11-26 | |
dc.departamentoes | Fisiología | es_ES |
dc.departamentoeu | Fisiologia | es_ES |
dc.subject.categoria | PSYCHIATRY AND MENTAL HEALTH | |