dc.contributor.author | Han, Jianlin | |
dc.contributor.author | Romoff, Todd T. | |
dc.contributor.author | Moriwaki, Hiroki | |
dc.contributor.author | Konno, Hiroyuki | |
dc.contributor.author | Soloshonok, Vadym Anatolievch | |
dc.date.accessioned | 2020-02-28T14:17:33Z | |
dc.date.available | 2020-02-28T14:17:33Z | |
dc.date.issued | 2019-11-19 | |
dc.identifier.citation | ACS Omega 4(21) : 18942-18947(2019) | es_ES |
dc.identifier.issn | 2470-1343 | |
dc.identifier.uri | http://hdl.handle.net/10810/41863 | |
dc.description.abstract | Enantiomerically pure tailor-made amino acids are in extremely high demand in nearly every sector of the health-related industries. In particular, the rapidly growing number of amino-acid-based pharmaceuticals calls for the development of advanced synthetic approaches featuring practicality and commercial viability. Here we provide a brief summary of the development of axially chiral tridentate Hamari ligands and their application for general asymmetric synthesis of various structural types of amino acids. The methodological diversity includes: dynamic kinetic resolution and (S)-/(R)-interconversion of unprotected amino acids and homologation of nucleophilic glycine equivalents via alkyl halide alkylation reactions as well as multiple-step transformations allowing preparation of polyfunctional and cyclic derivatives. The practicality of these methods is critically discussed. | es_ES |
dc.description.sponsorship | We gratefully acknowledge the financial support from the National Natural Science Foundation of China (No. 21761132021) and IKERBASQUE, Basque Foundation for Science. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Chemical Society | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | nucleophilic glycine | es_ES |
dc.subject | s/r interconversion | es_ES |
dc.subject | kinetic resolution | es_ES |
dc.subject | addition-reactions | es_ES |
dc.subject | alkylation | es_ES |
dc.subject | homologation | es_ES |
dc.subject | equivalents | es_ES |
dc.subject | derivatives | es_ES |
dc.subject | complexes | es_ES |
dc.subject | base | es_ES |
dc.title | Development of Hamari Ligands for Practical Asymmetric Synthesisof Tailor-Made Amino Acids | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | This is an open access article published under a Creative Commons Attribution (CC-BY)License, which permits unrestricted use, distribution and reproduction in any medium,provided the author and source are cited | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://pubs.acs.org/doi/10.1021/acsomega.9b02940 | es_ES |
dc.identifier.doi | 10.1021/acsomega.9b02940 | |
dc.departamentoes | Química orgánica I | es_ES |
dc.departamentoeu | Kimika organikoa I | es_ES |