Environmental enrichment shapes striatal spike-timing-dependent plasticity in vivo
dc.contributor.author | Morera Herreras, Teresa | |
dc.contributor.author | Gioanni, Yves | |
dc.contributor.author | Perez, Sylvie | |
dc.contributor.author | Vignoud, Gaetan | |
dc.contributor.author | Venance, Laurent | |
dc.date.accessioned | 2020-03-25T12:55:07Z | |
dc.date.available | 2020-03-25T12:55:07Z | |
dc.date.issued | 2019-12-19 | |
dc.identifier.citation | Scientific Reports 9 : (2019) // Article ID 1951 | es_ES |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | http://hdl.handle.net/10810/42329 | |
dc.description.abstract | Behavioural experience, such as environmental enrichment (EE), induces long-term effects on learning and memory. Learning can be assessed with the Hebbian paradigm, such as spike-timing-dependent plasticity (STDP), which relies on the timing of neuronal activity on either side of the synapse. Although EE is known to control neuronal excitability and consequently spike timing, whether EE shapes STDP remains unknown. Here, using in vivo long-duration intracellular recordings at the corticostriatal synapses we show that EE promotes asymmetric anti-Hebbian STDP, i.e. spike-timing-dependent-potentiation (tLTP) for post-pre pairings and spike-timing-dependent-depression (tLTD) for pre-post pairings, whereas animals grown in standard housing show mainly tLTD and a high failure rate of plasticity. Indeed, in adult rats grown in standard conditions, we observed unidirectional plasticity (mainly symmetric anti-Hebbian tLTD) within a large temporal window (similar to 200 ms). However, rats grown for two months in EE displayed a bidirectional STDP (tLTP and tLTD depending on spike timing) in a more restricted temporal window (similar to 100 ms) with low failure rate of plasticity. We also found that the effects of EE on STDP characteristics are influenced by the anaesthesia status: the deeper the anaesthesia, the higher the absence of plasticity. These findings establish a central role for EE and the anaesthetic regime in shaping in vivo, a synaptic Hebbian learning rule such as STDP. | es_ES |
dc.description.sponsorship | We thank the members of the LV laboratory for helpful suggestions and critical comments. TMH is a Research Fellow of University of Basque Government. This work was supported by grants from INSERM, College de France and CNRS. This work has been supported by grants from the Basque Country (PPGA19/15), INSERM, CNRS and College de France. T.M. was supported by a postdoctoral grant from the Basque government. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | synaptic plasticity | es_ES |
dc.subject | corticostriatal plasticity | es_ES |
dc.subject | learning rules | es_ES |
dc.subject | acquisition | es_ES |
dc.subject | memory | es_ES |
dc.subject | consequences | es_ES |
dc.subject | potentiation | es_ES |
dc.subject | circuits | es_ES |
dc.subject | neurons | es_ES |
dc.subject | impact | es_ES |
dc.title | Environmental enrichment shapes striatal spike-timing-dependent plasticity in vivo | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.nature.com/articles/s41598-019-55842-z | es_ES |
dc.identifier.doi | 10.1038/s41598-019-55842-z | |
dc.departamentoes | Farmacología | es_ES |
dc.departamentoeu | Farmakologia | es_ES |
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