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Fluorescence Microscopy of the HIV-1 Envelope

dc.contributor.authorCarravilla Palomanes, Pablo ORCID
dc.contributor.authorNieva Escandón, José Luis
dc.contributor.authorEggeling, Christian
dc.date.accessioned2020-04-23T18:21:03Z
dc.date.available2020-04-23T18:21:03Z
dc.date.issued2020-03-21
dc.identifier.citationViruses 12(3) : (2020) // Article ID 348es_ES
dc.identifier.issn1999-4915
dc.identifier.urihttp://hdl.handle.net/10810/42877
dc.description.abstractHuman immunodeficiency virus (HIV) infection constitutes a major health and social issue worldwide. HIV infects cells by fusing its envelope with the target cell plasma membrane. This process is mediated by the viral Env glycoprotein and depends on the envelope lipid composition. Fluorescent microscopy has been employed to investigate the envelope properties, and the processes of viral assembly and fusion, but the application of this technique to the study of HIV is still limited by a number of factors, such as the small size of HIV virions or the difficulty to label the envelope components. Here, we review fluorescence imaging studies of the envelope lipids and proteins, focusing on labelling strategies and model systems.es_ES
dc.description.sponsorshipPC was awarded a contract from the Basque Government Postdoctoral Programme (POS_2019_2_0022). JLN acknowledges financial support by the Spanish Government (BIO2015-64421-R (MINECO/AEI/FEDER UE) and RTI2018-095624-B-C21 (MCIU/AEI/FEDER UE) Grants) and the Basque Government (IT1196-19 Grant). CE acknowledges support from the Wolfson Imaging Centre Oxford (Christoffer Lagerholm), the Wolfson Foundation (18272), the Medical Research Council (MC_UU_12010/unit programmes G0902418 and MC_UU_12025), MRC/BBSRC/ESPRC (grant number MR/K01577X/1), the Wellcome Trust (104924/14/Z/14, 100262Z/12/Z, 098274/Z/12/Z and Strategic Award 091911 (107457/Z/15/Z, Advanced Micron Bioimaging Unit)), the Deutsche Forschungsgemeinschaft (Research unit 1905, Jena Excellence Cluster “Balance of the Microverse”, project no. 3162113987 – SFB 1278 (project C05), the Newton-Katip Celebi Institutional Links grant (352333122), and internal University of Oxford funding (EPA Cephalosporin Fund and John Fell Fund).es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/BIO2015-64421-Res_ES
dc.relationinfo:eu-repo/grantAgreement/MCIU/RTI2018-095624-B-C21es_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/
dc.subjectmicroscopyes_ES
dc.subjectHIVes_ES
dc.subjectenvelopees_ES
dc.subjectlipides_ES
dc.subjectmembranees_ES
dc.subjectEnves_ES
dc.subjectfluorescencees_ES
dc.subjectsuper-resolutiones_ES
dc.titleFluorescence Microscopy of the HIV-1 Envelopees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.date.updated2020-03-27T14:55:22Z
dc.rights.holder© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).es_ES
dc.relation.publisherversionhttps://www.mdpi.com/1999-4915/12/3/348es_ES
dc.identifier.doi10.3390/v12030348
dc.departamentoesBioquímica y biología molecular
dc.departamentoeuBiokimika eta biologia molekularra


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© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Except where otherwise noted, this item's license is described as © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).