Methylmercury Poisoning Induces Cardiac Electrical Remodeling and Increases Arrhythmia Susceptibility and Mortality
dc.contributor.author | Santos Ruybal, Mara Cristina P. | |
dc.contributor.author | Nascimento, Jose Hamilton M. | |
dc.contributor.author | Gallego Muñoz, Mónica | |
dc.contributor.author | Sottani, Thais Bazoti B. | |
dc.contributor.author | Medei, Emiliano H. | |
dc.contributor.author | Casis Sáenz, Oscar | |
dc.date.accessioned | 2020-06-01T12:20:58Z | |
dc.date.available | 2020-06-01T12:20:58Z | |
dc.date.issued | 2020-05-15 | |
dc.identifier.citation | International Journal of Molecular Sciences 21(10) : (2020) // Article ID 3490 | es_ES |
dc.identifier.issn | 1422-0067, | |
dc.identifier.uri | http://hdl.handle.net/10810/43665 | |
dc.description.abstract | This study aims to investigate the cardiac electrical remodeling associated with intoxication by methylmercury (MeHg). We evaluated the chronic effects of MeHg on in vivo electrocardiograms and on ex vivo action potentials and depolarizing (ICa-L) and repolarizing (Ito) currents. The acute effect of MeHg was evaluated on HEK293 cells expressing human ERG, Kv4.3 and KCNQ1/KCNE1 channels. Chronic MeHg treatment increased QTc and Tpeak–Tend interval duration, prolonged action potential duration and decreased amplitude of Ito and ICa-L. In addition, heterologously expressed IhKv4.3, IhERG or IhKCNQ1/KCNE1 decreased after acute exposure to MeHg at subnanomolar range. The introduction of the in vitro effects of MeHg in a computer model of human ventricular action potentials triggered early afterdepolarizations and arrhythmia. In conclusion, cardiac electrical remodeling induced by MeHg poisoning is related to the reduction of Ito and ICa-L. The acute effect of MeHg on hKv4.3; hERG and hKCNQ1/KCNE1 currents and their transposition to in silico models show an association between MeHg intoxication and acquired Long QT Syndrome in humans. MeHg can exert its high toxicity either after chronic or acute exposure to concentrations as low as picomolar. | es_ES |
dc.description.sponsorship | This work was supported by grants from the Gobierno Vasco PIBA2018-58 and GIC18/150. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | |
dc.subject | mercury | es_ES |
dc.subject | cardiac | es_ES |
dc.subject | electrical remodeling | es_ES |
dc.subject | ion current; arrhythmia | es_ES |
dc.title | Methylmercury Poisoning Induces Cardiac Electrical Remodeling and Increases Arrhythmia Susceptibility and Mortality | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2020-05-28T14:09:55Z | |
dc.rights.holder | 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/1422-0067/21/10/3490/htm | es_ES |
dc.identifier.doi | 10.3390/ijms21103490 | |
dc.departamentoes | Fisiología | |
dc.departamentoeu | Fisiologia |
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Except where otherwise noted, this item's license is described as 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).