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dc.contributor.authorRaslan, Ahmed
dc.contributor.authorSáenz del Burgo Martínez, Laura ORCID
dc.contributor.authorEspona Noguera, Albert
dc.contributor.authorOchoa de Retana Mendibil, Ana María ORCID
dc.contributor.authorSanjuán, María Luisa
dc.contributor.authorCañibano Hernández, Alberto
dc.contributor.authorGálvez Martín, Patricia
dc.contributor.authorCiriza Astrain, Jesús
dc.contributor.authorPedraz Muñoz, José Luis ORCID
dc.date.accessioned2020-07-07T08:29:04Z
dc.date.available2020-07-07T08:29:04Z
dc.date.issued2020-06-11
dc.identifier.citationPharmaceutics 12(6) : (2020) // Article ID 543es_ES
dc.identifier.issn1999-4923
dc.identifier.urihttp://hdl.handle.net/10810/45045
dc.description.abstractThe use of embedded cells within alginate matrices is a developing technique with great clinical applications in cell-based therapies. However, one feature that needs additional investigation is the improvement of alginate-cells viability, which could be achieved by integrating other materials with alginate to improve its surface properties. In recent years, the field of nanotechnology has shown the many properties of a huge number of materials. Graphene oxide (GO), for instance, seems to be a good choice for improving alginate cell viability and functionality. We previously observed that GO, coated with fetal bovine serum (FBS) within alginate hydrogels, improves the viability of embedded myoblasts. In the current research, we aim to study several proteins, specifically bovine serum albumin (BSA), type I collagen and elastin, to discern their impact on the previously observed improvement on embedded myoblasts within alginate hydrogels containing GO coated with FBS. Thus, we describe the mechanisms of the formation of BSA, collagen and elastin protein layers on the GO surface, showing a high adsorption by BSA and elastin, and a decreasing GO impedance and capacitance. Moreover, we described a better cell viability and protein release from embedded cells within hydrogels containing protein-coated GO. We conclude that these hybrid hydrogels could provide a step forward in regenerative medicine.es_ES
dc.description.sponsorshipThis research was funded by the University of the Basque Country UPV/EHU and the Basque Country Government (Grupos Consolidados, No ref: IT907-16).es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/
dc.subjectgraphene oxidees_ES
dc.subjectbovine serum albumines_ES
dc.subjecttype I collagenes_ES
dc.subjectelastines_ES
dc.subjectalginate hydrogelses_ES
dc.subjectcell viabilityes_ES
dc.titleBSA- and Elastin-Coated GO, but Not Collagen-Coated GO, Enhance the Biological Performance of Alginate Hydrogelses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.date.updated2020-06-30T16:27:39Z
dc.rights.holder2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).es_ES
dc.relation.publisherversionhttps://www.mdpi.com/1999-4923/12/6/543/htmes_ES
dc.identifier.doi10.3390/pharmaceutics12060543
dc.departamentoesFarmacia y ciencias de los alimentos
dc.departamentoeuFarmazia eta elikagaien zientziak


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2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Except where otherwise noted, this item's license is described as 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).