Predictive Value of Carcinoembryonic Antigen in Symptomatic Patients without Colorectal Cancer: A Post-Hoc Analysis within the COLONPREDICT Cohort
dc.contributor.author | Pin Vieito, Noel | |
dc.contributor.author | Iglesias, María José | |
dc.contributor.author | Remedios, David | |
dc.contributor.author | Álvarez Sánchez, Victoria | |
dc.contributor.author | Fernández Bañares, Fernando | |
dc.contributor.author | Boadas, Jaume | |
dc.contributor.author | Martínez Bauer, Eva | |
dc.contributor.author | Campo, Rafael | |
dc.contributor.author | Bujanda Fernández de Pierola, Luis | |
dc.contributor.author | Ferrández, Ángel | |
dc.contributor.author | Piñol, Virginia | |
dc.contributor.author | Rodríguez Alcalde, Daniel | |
dc.contributor.author | Menéndez Rodríguez, Martín | |
dc.contributor.author | García Morales, Natalia | |
dc.contributor.author | Pérez Mosquera, Cristina | |
dc.contributor.author | Cubiella, Joaquín | |
dc.date.accessioned | 2021-01-05T11:22:40Z | |
dc.date.available | 2021-01-05T11:22:40Z | |
dc.date.issued | 2020-12-02 | |
dc.identifier.citation | Diagnostics 10(12) : (2020) // Article ID 1036 | es_ES |
dc.identifier.issn | 2075-4418 | |
dc.identifier.uri | http://hdl.handle.net/10810/49639 | |
dc.description.abstract | We aimed to assess the risk of cancer in patients with abdominal symptoms after a complete colonoscopy without colorectal cancer (CRC), according to the carcinoembryonic antigen (CEA) concentration, as well as its diagnostic accuracy. For this purpose, we performed a post-hoc analysis within a cohort of 1431 patients from the COLONPREDICT study, prospectively designed to assess the fecal immunochemical test accuracy in detecting CRC. Over 36.5 ± 8.4 months, cancer was detected in 115 (8%) patients. Patients with CEA values higher than 3 ng/mL revealed an increased risk of cancer (HR 2.0, 95% CI 1.3–3.1), CRC (HR 4.4, 95% CI 1.1–17.7) and non-gastrointestinal cancer (HR 1.7, 95% CI 1.0–2.8). A new malignancy was detected in 51 (3.6%) patients during the first year and three variables were independently associated: anemia (OR 2.8, 95% CI 1.3–5.8), rectal bleeding (OR 0.3, 95% CI 0.1–0.7) and CEA level >3 ng/mL (OR 3.4, 95% CI 1.7–7.1). However, CEA was increased only in 31.8% (95% CI, 16.4–52.7%) and 50% (95% CI, 25.4–74.6%) of patients with and without anemia, respectively, who would be diagnosed with cancer during the first year of follow-up. On the basis of this information, CEA should not be used to assist in the triage of patients presenting with lower bowel symptoms who have recently been ruled out a CRC | es_ES |
dc.description.sponsorship | This work was supported by Spain’s Carlos III Healthcare Institute by means of project PI17/00837 (Co-funded by European Regional Development Fund/European Social Fund “A way to make Europe”/“Investing in your future” | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | |
dc.subject | biochemical diagnosis | es_ES |
dc.subject | carcinoembryonic antigen | es_ES |
dc.subject | colonoscopy | es_ES |
dc.subject | early cancer | es_ES |
dc.subject | gastrointestinal cancer | es_ES |
dc.subject | symptoms | es_ES |
dc.subject | tumor biomarkers | es_ES |
dc.title | Predictive Value of Carcinoembryonic Antigen in Symptomatic Patients without Colorectal Cancer: A Post-Hoc Analysis within the COLONPREDICT Cohort | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2020-12-24T15:54:46Z | |
dc.rights.holder | 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/2075-4418/10/12/1036/htm | es_ES |
dc.identifier.doi | 10.3390/diagnostics10121036 | |
dc.departamentoes | Medicina | |
dc.departamentoeu | Medikuntza |
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Except where otherwise noted, this item's license is described as 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).