Advances in the Multi-Orthogonal Folding of Single Polymer Chains into Single-Chain Nanoparticles
dc.contributor.author | Blázquez Martín, Agustín | |
dc.contributor.author | Verde Sesto, Ester | |
dc.contributor.author | Moreno Segurado, Angel José | |
dc.contributor.author | Arbe Méndez, María Aranzazu | |
dc.contributor.author | Colmenero de León, Juan | |
dc.contributor.author | Pomposo Alonso, José Adolfo | |
dc.date.accessioned | 2021-01-26T11:55:39Z | |
dc.date.available | 2021-01-26T11:55:39Z | |
dc.date.issued | 2021-01-18 | |
dc.identifier.citation | Polymers 13(2) : (2021) // Article ID 293 | es_ES |
dc.identifier.issn | 2073-4360 | |
dc.identifier.uri | http://hdl.handle.net/10810/49884 | |
dc.description.abstract | The folding of certain proteins (e.g., enzymes) into perfectly defined 3D conformations via multi-orthogonal interactions is critical to their function. Concerning synthetic polymers chains, the “folding” of individual polymer chains at high dilution via intra-chain interactions leads to so-called single-chain nanoparticles (SCNPs). This review article describes the advances carried out in recent years in the folding of single polymer chains into discrete SCNPs via multi-orthogonal interactions using different reactive chemical species where intra-chain bonding only occurs between groups of the same species. First, we summarize results from computer simulations of multi-orthogonally folded SCNPs. Next, we comprehensively review multi-orthogonally folded SCNPs synthesized via either non-covalent bonds or covalent interactions. Finally, we conclude by summarizing recent research about multi-orthogonally folded SCNPs prepared through both reversible (dynamic) and permanent bonds. | es_ES |
dc.description.sponsorship | This research was funded by Gipuzkoako Foru Aldundia -Programa Red Gipuzkoana de Ciencia, Tecnología e Innovación 2019-, grant number 2019-CIEN-000050-01; Basque Government, grant number IT-1175-19; and MCIU/AEI/FEDER, UE, grant number PGC2018-094548-B-I00. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.relation | info:eu-repo/grantAgreement/MCIU/PGC2018-094548-B-I00. | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | |
dc.subject | folding | es_ES |
dc.subject | interactions | es_ES |
dc.subject | single-chain nanoparticles | es_ES |
dc.title | Advances in the Multi-Orthogonal Folding of Single Polymer Chains into Single-Chain Nanoparticles | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2021-01-22T15:48:56Z | |
dc.rights.holder | 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/2073-4360/13/2/293/htm | es_ES |
dc.identifier.doi | 10.3390/polym13020293 | |
dc.departamentoes | Ciencia y tecnología de polímeros | |
dc.departamentoeu | Polimeroen zientzia eta teknologia |
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Except where otherwise noted, this item's license is described as 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).