The Sum of Plasma Fatty Acids iso16:0, iso17:0, trans11-18:1, cis9, trans11-CLA, and cis6-18:1 as Biomarker of Dairy Intake Established in an Intervention Study and Validated in the EPIC Cohort of Gipuzkoa
dc.contributor.author | Berriozabalgoitia, Alaitz | |
dc.contributor.author | Ruiz de Gordoa Arroniz, Juan Carlos Alfonso ![]() | |
dc.contributor.author | Renobales Scheifler, María Mercedes de | |
dc.contributor.author | Amores Olazaguirre, Gustavo ![]() | |
dc.contributor.author | Rodríguez Barrón, Luis Javier ![]() | |
dc.contributor.author | Amiano, Pilar | |
dc.contributor.author | Dorronsoro, Miren | |
dc.contributor.author | Perea, Zelai | |
dc.contributor.author | Virto Lecuona, María Dolores ![]() | |
dc.date.accessioned | 2021-03-03T10:59:26Z | |
dc.date.available | 2021-03-03T10:59:26Z | |
dc.date.issued | 2021-02-22 | |
dc.identifier.citation | Nutrients 13(2) : (2021) // Article ID 702 | es_ES |
dc.identifier.issn | 2072-6643 | |
dc.identifier.uri | http://hdl.handle.net/10810/50434 | |
dc.description.abstract | The questioned reliability of 15:0, 17:0, and trans9-16:1 acids as biomarkers of dairy fat intake also questions the relationship between the intake of these products and their health effects. Two studies were conducted in the same geographical region. In an intervention study, volunteers followed a diet rich in dairy products followed by a diet without dairy products. Plasma and erythrocyte fatty acids (FA) were analyzed, and their correlations with dairy product intakes were tested. The FA biomarkers selected were validated in the Gipuzkoa cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC) observational study. The correlation coefficients between plasma concentrations of iso16:0, iso17:0, trans11-18:1, cis9, trans11-18:2, and cis6-18:1 and the dairy fat ingested are similar in both studies, indicating that their concentration increases by 0.8 µmol/L per gram of dairy fat ingested. The biomarkers are positively related to plasma triglycerides (r = 0.324 and 0.204 in the intervention and observational studies, respectively) and total cholesterol (r = 0.459 and 0.382), but no correlation was found between the biomarkers and atherogenicity indexes. In conclusion, the sum of the plasma concentration of the selected FAs can be used as biomarkers of dairy product consumption. A linear relationship exists between their plasma concentrations and ruminant product intake. These biomarkers allow for obtaining consistent relationships between dairy intake and plasma biochemical parameters. | es_ES |
dc.description.sponsorship | This research was funded by Basque Government (grant to Research Groups IT944-16). A.B. received a research grant from the University of the Basque Country, call 2009. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | |
dc.subject | dairy products | es_ES |
dc.subject | dairy fat | es_ES |
dc.subject | rumenic acid | es_ES |
dc.subject | vaccenic acid | es_ES |
dc.subject | petroselinic acid | es_ES |
dc.subject | iso fatty acids | es_ES |
dc.subject | biomarkers | es_ES |
dc.subject | plasma | es_ES |
dc.subject | atherogenicity indexes | es_ES |
dc.title | The Sum of Plasma Fatty Acids iso16:0, iso17:0, trans11-18:1, cis9, trans11-CLA, and cis6-18:1 as Biomarker of Dairy Intake Established in an Intervention Study and Validated in the EPIC Cohort of Gipuzkoa | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2021-02-26T14:43:13Z | |
dc.rights.holder | 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/2072-6643/13/2/702/htm | es_ES |
dc.identifier.doi | 10.3390/nu13020702 | |
dc.departamentoes | Bioquímica y biología molecular | |
dc.departamentoes | Farmacia y ciencias de los alimentos | |
dc.departamentoeu | Biokimika eta biologia molekularra | |
dc.departamentoeu | Farmazia eta elikagaien zientziak |
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Except where otherwise noted, this item's license is described as 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).