dc.contributor.author | Urizar Arenaza, Itziar ![ORCID](/themes/Mirage2//images/orcid_16x16.png) | |
dc.contributor.author | Benedicto García, Aitor | |
dc.contributor.author | Pérez Valle, Arantza | |
dc.contributor.author | Osinalde Moraleja, Nerea ![ORCID](/themes/Mirage2//images/orcid_16x16.png) | |
dc.contributor.author | Akimov, Vyacheslav | |
dc.contributor.author | Muñoa Hoyos, Iraia ![ORCID](/themes/Mirage2//images/orcid_16x16.png) | |
dc.contributor.author | Rodríguez Pérez, José Antonio ![ORCID](/themes/Mirage2//images/orcid_16x16.png) | |
dc.contributor.author | Asumendi Mallea, Aintzane ![ORCID](/themes/Mirage2//images/orcid_16x16.png) | |
dc.contributor.author | Boyano López, María Dolores ![ORCID](/themes/Mirage2//images/orcid_16x16.png) | |
dc.contributor.author | Blagoev, Blagoy | |
dc.contributor.author | Kratchmarova, Irina | |
dc.contributor.author | Subirán Ciudad, Nerea ![ORCID](/themes/Mirage2//images/orcid_16x16.png) | |
dc.date.accessioned | 2021-03-23T09:20:22Z | |
dc.date.available | 2021-03-23T09:20:22Z | |
dc.date.issued | 2021-02-11 | |
dc.identifier.citation | Scientific Reports 11(1) : (2021) // Article ID 3583 | es_ES |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | http://hdl.handle.net/10810/50743 | |
dc.description.abstract | Human sperm protein associated with the nucleus on the X chromosome (SPANX) genes encode a protein family (SPANX-A, -B, -C and -D), whose expression is limited to the testis and spermatozoa in normal tissues and various tumour cells. SPANX-A/D proteins have been detected in metastatic melanoma cells, but their contribution to cancer development and the underlying molecular mechanisms of skin tumourigenesis remain unknown. Combining functional and proteomic approaches, the present work describes the presence of SPANX-A/D in primary and metastatic human melanoma cells and how it promotes pro-tumoural processes such as cell proliferation, motility and migration. We provide insights into the molecular features of skin tumourigenesis, describing for the first time a multifunctional role of the SPANX-A/D protein family in nuclear function, energy metabolism and cell survival, considered key hallmarks of cancer. A better comprehension of the SPANX-A/D protein subfamily and its molecular mechanisms will help to describe new aspects of tumour cell biology and develop new therapeutic targets and tumour-directed pharmacological drugs for skin tumours | es_ES |
dc.description.sponsorship | University of the Basque Country (UPV/EHU) (GIU19/018). IU-A is supported by a fellowship from the University of the Basque Country (UPV/EHU). IM-H is supported by a fellowship from the Basque Government. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | human sperm protein | es_ES |
dc.subject | X chromosome (SPANX) genes | es_ES |
dc.subject | SPANX-A/D proteins | es_ES |
dc.subject | metastatic melanoma cells | es_ES |
dc.subject | skin tumourigenesis | es_ES |
dc.subject | skin tumours | es_ES |
dc.title | The Multifunctional Role of SPANX-A/D Protein Subfamily in the Promotion of Pro-Tumoural Processes in Human Melanoma | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | This article is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0) | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.nature.com/articles/s41598-021-83169-1 | es_ES |
dc.identifier.doi | 10.1038/s41598-021-83169-1 | |
dc.departamentoes | Biología celular e histología | es_ES |
dc.departamentoes | Bioquímica y biología molecular | es_ES |
dc.departamentoes | Fisiología | es_ES |
dc.departamentoes | Genética, antropología física y fisiología animal | es_ES |
dc.departamentoeu | Biokimika eta biologia molekularra | es_ES |
dc.departamentoeu | Fisiologia | es_ES |
dc.departamentoeu | Genetika,antropologia fisikoa eta animalien fisiologia | es_ES |
dc.departamentoeu | Zelulen biologia eta histologia | es_ES |