Astrocyte dystrophy in ageing brain parallels impaired synaptic plasticity
dc.contributor.author | Popov, Alexander | |
dc.contributor.author | Brazhe, Alexey | |
dc.contributor.author | Denisov, Pavel | |
dc.contributor.author | Sutyagina, Oksana | |
dc.contributor.author | Li, Li | |
dc.contributor.author | Lazareva, Natalia | |
dc.contributor.author | Verkhratsky, Alexei | |
dc.contributor.author | Semyanov, Alexey | |
dc.date.accessioned | 2021-03-24T13:31:35Z | |
dc.date.available | 2021-03-24T13:31:35Z | |
dc.date.issued | 2021-03 | |
dc.identifier.citation | Aging cell 20(3) : (2021) // Article ID e13334 | es_ES |
dc.identifier.issn | 1474-9726 | |
dc.identifier.uri | http://hdl.handle.net/10810/50765 | |
dc.description.abstract | Little is known about age-dependent changes in structure and function of astrocytes and of the impact of these on the cognitive decline in the senescent brain. The prevalent view on the age-dependent increase in reactive astrogliosis and astrocytic hypertrophy requires scrutiny and detailed analysis. Using two-photon microscopy in conjunction with 3D reconstruction, Sholl and volume fraction analysis, we demonstrate a significant reduction in the number and the length of astrocytic processes, in astrocytic territorial domains andin astrocyte-to-astrocyte coupling in the aged brain. Probing physiology of astrocytes with patch clamp, and Ca2+ imaging revealed deficits in K+ and glutamate clearance and spatiotemporal reorganisation of Ca2+ events in old astrocytes. These changes paralleled impaired synaptic long-term potentiation (LTP) in hippocampal CA1 in old mice. Our findings may explain the astroglial mechanisms of age-dependent decline in learning and memory. | es_ES |
dc.description.sponsorship | The research was supported by the Russian Science Foundation grant 20‐14‐00241. | es_ES |
dc.language.iso | eng | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | K+ buffering | es_ES |
dc.subject | ageing | es_ES |
dc.subject | astrocytic complexity | es_ES |
dc.subject | astrocytic cradle | es_ES |
dc.subject | glutamate uptake | es_ES |
dc.subject | perisynaptic astrocytic processes | es_ES |
dc.title | Astrocyte dystrophy in ageing brain parallels impaired synaptic plasticity | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | 2021 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/10.1111/acel.13334 | es_ES |
dc.identifier.doi | 10.1111/acel.13334 | |
dc.departamentoes | Neurociencias | es_ES |
dc.departamentoeu | Neurozientziak | es_ES |
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Except where otherwise noted, this item's license is described as 2021 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.