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dc.contributor.authorXu, Cheng-Jian
dc.contributor.authorGruzieva, Olena
dc.contributor.authorQi, Cancan
dc.contributor.authorEsplugues, Ana
dc.contributor.authorGehring, Ulrike
dc.contributor.authorBergström, Anna
dc.contributor.authorMason, Dan
dc.contributor.authorChatzi, Leda
dc.contributor.authorPorta, Daniela
dc.contributor.authorLodrup Carlsen, Karin C.
dc.contributor.authorBaïz, Nour
dc.contributor.authorMadore, Anne-Marie
dc.contributor.authorAlenius, Harri
dc.contributor.authorVan Rijkom, Bianca
dc.contributor.authorJankipersadsing, Soesma A.
dc.contributor.authorVan der Vlies, Pieter
dc.contributor.authorKull, Inger
dc.contributor.authorVan Hage, Marianne
dc.contributor.authorBustamante, Mariona
dc.contributor.authorLertxundi Manterola, Aitana
dc.contributor.authorTorrent, Matias
dc.contributor.authorSantore, Gillian
dc.contributor.authorFantini, Maria Pia
dc.contributor.authorHovland, Vegard
dc.contributor.authorPesce, Giancarlo
dc.contributor.authorBIOS Consortium
dc.contributor.authorFyhrquist, Nanna
dc.contributor.authorLaatikainen, Tiina
dc.contributor.authorNawijn, Martijn C.
dc.contributor.authorLi, Yang
dc.contributor.authorWijmenga, Cisca
dc.contributor.authorNetea, Mihai G.
dc.contributor.authorBousquet, Jean
dc.contributor.authorAnto, Josep M.
dc.contributor.authorLaprise, Catherine
dc.contributor.authorHaahtela, Tari
dc.contributor.authorAnnesi-Maesano, Isabella
dc.contributor.authorCarlsen, Kai-Håkon
dc.contributor.authorGori, Davide
dc.contributor.authorKogevinas, Manolis
dc.contributor.authorWright, John
dc.contributor.authorSöderhäll, Cilla
dc.contributor.authorVonk, Judith M.
dc.contributor.authorSunyer, Jordi
dc.contributor.authorMelén, Erik
dc.contributor.authorKoppelman, Gerard H.
dc.date.accessioned2021-03-25T13:51:54Z
dc.date.available2021-03-25T13:51:54Z
dc.date.issued2021-03
dc.identifier.citationThe Journal of allergy and clinical immunology 147(3) : 1031-1040 (2021)es_ES
dc.identifier.issn1097-6825
dc.identifier.urihttp://hdl.handle.net/10810/50775
dc.description.abstractBACKGROUND: Differential DNA methylation associated with allergy might provide novel insights into the shared or unique etiology of asthma, rhinitis, and eczema. OBJECTIVE: We sought to identify DNA methylationprofilesassociated with childhood allergy. METHODS: Within the European Mechanisms of the Development of Allergy (MeDALL) consortium, we performed an epigenome-wide association study of whole blood DNA methylation by using a cross-sectional design. Allergy was defined as having symptoms from at least 1 allergic disease (asthma, rhinitis, or eczema) and positive serum-specific IgE to common aeroallergens. The discovery study included 219 case patients and 417 controls at age 4 years and 228 case patients and 593 controls at age 8 years from 3 birth cohorts, with replication analyses in 325 case patients and 1111 controls. We performed additional analyses on 21 replicated sites in 785 case patients and 2124 controls by allergic symptoms only from 8 cohorts, 3 of which were not previously included in analyses. RESULTS: We identified 80 differentially methylated CpG sites that showed a 1% to 3% methylation difference in the discovery phase, of which 21 (including 5 novel CpG sites) passed genome-wide significance after meta-analysis. All 21 CpG sites were also significantly differentially methylated with allergic symptoms and shared between asthma, rhinitis, and eczema. The 21 CpG sites mapped to relevant genes, including ACOT7, LMAN3, and CLDN23. All 21 CpG sties were differently methylated in asthma in isolated eosinophils, and 10 were replicated in respiratory epithelium. CONCLUSION: Reduced whole blood DNA methylation at 21 CpG sites was significantly associated with childhood allergy. The findings provide novel insights into the shared molecular mechanisms underlying asthma, rhinitis, and eczema.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectDNA methylationes_ES
dc.subjectepigeneticses_ES
dc.subjectIgEes_ES
dc.subjectallergyes_ES
dc.subjectchildrenes_ES
dc.titleShared DNA methylation signatures in childhood allergy: The MeDALL studyes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holder2020 The Authors. Published by Elsevier Inc. on behalf of the American Academy ofAllergy, Asthma & Immunology. This is an open access article under the CC BY li-cense (http://creativecommons.org/licenses/by/4.0/)es_ES
dc.rights.holderAtribución 3.0 España*
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0091674920317668?via%3Dihubes_ES
dc.identifier.doi10.1016/j.jaci.2020.11.044
dc.departamentoesMedicina preventiva y salud públicaes_ES
dc.departamentoeuPrebentzio medikuntza eta osasun publikoaes_ES


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2020 The Authors. Published by Elsevier Inc. on behalf of the American Academy ofAllergy, Asthma & Immunology. This is an open access article under the CC BY li-cense (http://creativecommons.org/licenses/by/4.0/)
Except where otherwise noted, this item's license is described as 2020 The Authors. Published by Elsevier Inc. on behalf of the American Academy ofAllergy, Asthma & Immunology. This is an open access article under the CC BY li-cense (http://creativecommons.org/licenses/by/4.0/)