Ugi Reaction on α-Phosphorated Ketimines for the Synthesis of Tetrasubstituted α-Aminophosphonates and Their Applications as Antiproliferative Agents

López Francés, Adrián; Del Corte Solaguren-Beascoa, Xabier; Martínez de Marigorta Izaga, Edorta; Palacios Gambra, Francisco Javier; Vicario Hernando, Javier

dc.contributor.author	López Francés, Adrián
dc.contributor.author	Del Corte Solaguren-Beascoa, Xabier
dc.contributor.author	Martínez de Marigorta Izaga, Edorta
dc.contributor.author	Palacios Gambra, Francisco Javier
dc.contributor.author	Vicario Hernando, Javier
dc.date.accessioned	2021-04-14T10:01:09Z
dc.date.available	2021-04-14T10:01:09Z
dc.date.issued	2021-03-16
dc.identifier.citation	Molecules 26(6) : (2021) // Article ID 1654	es_ES
dc.identifier.issn	1420-3049
dc.identifier.uri	http://hdl.handle.net/10810/50925
dc.description.abstract	An Ugi three-component reaction using preformed α-phosphorated N-tosyl ketimines with different isocyanides in the presence of a carboxylic acid affords tetrasubstituted α-aminophosphonates. Due to the high steric hindrance, the expected acylated amines undergo a spontaneous elimination of the acyl group. The reaction is applicable to α-aryl ketimines bearing a number of substituents and several isocyanides. In addition, the densely substituted α-aminophosphonate substrates showed in vitro cytotoxicity, inhibiting the growth of carcinoma human tumor cell line A549 (carcinomic human alveolar basal epithelial cell).	es_ES
dc.description.sponsorship	Financial support by Ministerio de Economía, Industria y Competividad (MINECO, CTQ-2015-67871R) and Gobierno Vasco (GV, IT 992-16) is gratefully acknowledged. X.d.C. and A.L.-F. thank the Basque Country Government for a predoctoral grant.	es_ES
dc.language.iso	eng	es_ES
dc.publisher	MDPI	es_ES
dc.relation	info:eu-repo/grantAgreement/MINECO/CTQ-2015-67871R	es_ES
dc.rights	info:eu-repo/semantics/openAccess	es_ES
dc.rights.uri	http://creativecommons.org/licenses/by/3.0/es/
dc.subject	multicomponent synthesis	es_ES
dc.subject	Ugi reaction	es_ES
dc.subject	α-aminophosphonates	es_ES
dc.subject	tetrasubstituted carbons	es_ES
dc.subject	antiproliferative effect	es_ES
dc.title	Ugi Reaction on α-Phosphorated Ketimines for the Synthesis of Tetrasubstituted α-Aminophosphonates and Their Applications as Antiproliferative Agents	es_ES
dc.type	info:eu-repo/semantics/article	es_ES
dc.date.updated	2021-03-26T14:09:33Z
dc.rights.holder	2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).	es_ES
dc.relation.publisherversion	https://www.mdpi.com/1420-3049/26/6/1654/htm	es_ES
dc.identifier.doi	10.3390/molecules26061654
dc.departamentoes	Química orgánica I
dc.departamentoeu	Kimika organikoa I

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2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

Except where otherwise noted, this item's license is described as 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).