Antioxidant activities and selenogene transcription in the european sea bass (Dicentrarchus labrax) liver depend, in a non-linear manner, on the Se/Hg molar tatio of the feeds
dc.contributor.author | Espino, Marinelle | |
dc.contributor.author | Eguiraun Martínez, Harkaitz | |
dc.contributor.author | Diaz de Cerio Arruabarrena, Oihane | |
dc.contributor.author | Carrero Hernández, José Antonio | |
dc.contributor.author | Etxebarria Loizate, Nestor | |
dc.contributor.author | Martínez Galarza, María Iciar | |
dc.date.accessioned | 2021-08-04T07:54:45Z | |
dc.date.available | 2021-08-04T07:54:45Z | |
dc.date.issued | 2021-07-01 | |
dc.identifier.citation | Biological Trace Element Research (2021) | es_ES |
dc.identifier.issn | 0163-4984 | |
dc.identifier.issn | 1559-0720 | |
dc.identifier.uri | http://hdl.handle.net/10810/52647 | |
dc.description.abstract | [EN] Feeding 3.9 and 6.7 mg Hg/kg (Se/Hg molar ratios of 0.8 and 0.4, respectively) for 14 days negatively affected Dicentrarchus labrax growth and total DNTB- and thioredoxin-reductase (TrxR) activities and the transcription of four redox genes (txn1, gpx1, txnrd3, and txnrd2) in the liver, but a diet with 0.5 mg Hg/kg (Se/Hg molar ratio 6.6) slightly increased both reductase activities and the transcription of txn1, gpx1, and txnrd2. Feeding 6.7 mg Hg/kg for 53 days downregulated the genes of the thioredoxin system (txn1, txnrd3, and txnrd2) but upregulated gpx1, confirming the previously proposed complementarity among the antioxidant systems. Substitution of 20% of the feed by thawed white fish (hake) slightly counteracted the negative effects of Hg. The effects were not statistically significant and were dependent, in a non-linear manner, on the Se/Hg molar ratio of the feed but not on its Hg concentration. These results stress the need to consider the Se/Hg molar ratio of the feed/ food when evaluating the toxicity of Hg. | es_ES |
dc.description.sponsorship | The work was supported by grants from the Spanish MINECO (RTC-2014–2837-2- “SELATUN: Minimización de la problemática del mercurio del atún y valorización del atún como alimento saludable, Programa Retos-Colaboración 2014” and CTM2012-40203-C02-01- “BMW: Biomarcadores estándar de base científica en mejillón para diagnosticar y monitorizar los efectos biológicos de la polución en el Golfo de Bizkaia: implementación de la DEME”), Euskampus Fundazioa- Campus of International Excellence (307615SAA2), and from the Basque Government Elkartek Grant KK-2016/00057- “MAROMEGA: Nuevas alternativas para la producción de omega-3 a partir de recursos marinos.” The funding sources had no involvement in the preparation of this manuscript. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Springer Nature ; Humana Press | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/RTC-2014–2837-2 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/CTM2012-40203-C02-01 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | mercury (Hg) | es_ES |
dc.subject | selenium (Se) | es_ES |
dc.subject | thioredoxin reductase | es_ES |
dc.subject | glutathione peroxidase | es_ES |
dc.subject | selenogene transcription | es_ES |
dc.subject | seafood | es_ES |
dc.subject | fish | es_ES |
dc.subject | Dicentrarchus labrax | es_ES |
dc.title | Antioxidant activities and selenogene transcription in the european sea bass (Dicentrarchus labrax) liver depend, in a non-linear manner, on the Se/Hg molar tatio of the feeds | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://rdcu.be/crBtt | es_ES |
dc.identifier.doi | 10.1007/s12011-021-02835-7 | |
dc.departamentoes | Expresión gráfica y proyectos de ingeniería | es_ES |
dc.departamentoes | Química aplicada | es_ES |
dc.departamentoes | Zoología y biología celular animal | es_ES |
dc.departamentoeu | Adierazpen grafikoa eta ingeniaritzako proiektuak | es_ES |
dc.departamentoeu | Kimika aplikatua | es_ES |
dc.departamentoeu | Zoologia eta animalia zelulen biologia | es_ES |
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