Quantification of Ceftaroline in Human Plasma Using High-Performance Liquid Chromatography with Ultraviolet Detection: Application to Pharmacokinetic Studies
dc.contributor.author | Alarcia Lacalle, Ana | |
dc.contributor.author | Barrasa González, Helena | |
dc.contributor.author | Maynar, Javier | |
dc.contributor.author | Canut Blasco, Andrés | |
dc.contributor.author | Gómez González, Carmen | |
dc.contributor.author | Solinís Aspiazu, María Ángeles | |
dc.contributor.author | Isla Ruiz, Arantxazu | |
dc.contributor.author | Rodríguez Gascón, Alicia | |
dc.date.accessioned | 2021-08-04T10:44:16Z | |
dc.date.available | 2021-08-04T10:44:16Z | |
dc.date.issued | 2021-06-25 | |
dc.identifier.citation | Pharmaceutics 13(7) : (2021) // Article ID 959 | es_ES |
dc.identifier.issn | 1999-4923 | |
dc.identifier.uri | http://hdl.handle.net/10810/52649 | |
dc.description.abstract | This study was conducted to develop a rapid, simple and reproducible method for the quantification of ceftaroline in plasma samples by high-performance liquid chromatography with ultraviolet detection (HPLC-UV). Sample processing consisted of methanol precipitation and then, after centrifugation, the supernatant was injected into the HPLC system, working in isocratic mode. Ceftaroline was detected at 238 nm at a short acquisition time (less than 5 min). The calibration curve was linear over the concentration range from 0.25 to 40 µg/mL, and the method appeared to be selective, precise and accurate. Ceftaroline in plasma samples was stable at −80 °C for at least 3 months. The method was successfully applied to characterize the pharmacokinetic profile of ceftaroline in two critically ill patients and to evaluate whether the pharmacokinetic/pharmacodynamic (PK/PD) target was reached or not with the dose regimen administered. | es_ES |
dc.description.sponsorship | This research was funded by Department of Education of the Basque Government (PIBA 2019-57) and by the University of the Basque Country UPV/EHU (GIU 17/32). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | |
dc.subject | ceftaroline fosamil | es_ES |
dc.subject | HPLC | es_ES |
dc.subject | pharmacokinetics | es_ES |
dc.subject | pharmacokinetics/pharmacodynamics | es_ES |
dc.title | Quantification of Ceftaroline in Human Plasma Using High-Performance Liquid Chromatography with Ultraviolet Detection: Application to Pharmacokinetic Studies | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2021-07-23T13:28:00Z | |
dc.rights.holder | 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/1999-4923/13/7/959/htm | es_ES |
dc.identifier.doi | 10.3390/pharmaceutics13070959 | |
dc.departamentoes | Farmacia y ciencias de los alimentos | |
dc.departamentoeu | Farmazia eta elikagaien zientziak |
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Except where otherwise noted, this item's license is described as 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).