dc.contributor.author | González Ortega, Itxaso | |
dc.contributor.author | Vega Pérez, Patricia | |
dc.contributor.author | Echeburúa Odriozola, Enrique ![ORCID](/themes/Mirage2//images/orcid_16x16.png) | |
dc.contributor.author | Alberich, Susana ![ORCID](/themes/Mirage2//images/orcid_16x16.png) | |
dc.contributor.author | Fernández Sevillano, Jessica | |
dc.contributor.author | Barbeito, Sara | |
dc.contributor.author | Balanzá Martínez, Vicent | |
dc.contributor.author | Vieta, Eduard | |
dc.contributor.author | Lorente-Rovira, Esther | |
dc.contributor.author | Luengo, Ana | |
dc.contributor.author | Cerrillo, Ester | |
dc.contributor.author | Crespo, José Manuel | |
dc.contributor.author | Matute Almau, Carlos José | |
dc.contributor.author | González Pinto Arrillaga, Ana María ![ORCID](/themes/Mirage2//images/orcid_16x16.png) | |
dc.date.accessioned | 2021-08-05T08:15:05Z | |
dc.date.available | 2021-08-05T08:15:05Z | |
dc.date.issued | 2021-07-06 | |
dc.identifier.citation | International Journal of Environmental Research and Public Health 18(14) : (2021) // Article ID 7239 | es_ES |
dc.identifier.issn | 1660-4601 | |
dc.identifier.uri | http://hdl.handle.net/10810/52696 | |
dc.description.abstract | Introduction: There is evidence that early intervention contributes to improving the prognosis and course of first-episode psychosis (FEP). However, further randomised treatment clinical trials are needed. Objectives: The aim of this study was to compare the efficacy of a combined clinical treatment involving Cognitive Behavioural Therapy (CBT) as an adjunctive to treatment-as-usual (TAU) (CBT+TAU) versus TAU alone for FEP. Patients and methods: In this multicentre, single-blind, randomised controlled trial, 177 participants were randomly allocated to either CBT+TAU or TAU. The primary outcome was post-treatment patient functioning. Results: The CBT+TAU group showed a greater improvement in functioning, which was measured using the Global Assessment Functioning (GAF) and Functioning Assessment Short Test (FAST), compared to the TAU group post-treatment. The CBT+TAU participants exhibited a greater decline in depressive, negative, and general psychotic symptoms; a better awareness of the disease and treatment adherence; and a greater increase in brain-derived neurotrophic factor levels than TAU participants. Conclusions: Early intervention based on a combined clinical treatment involving CBT as an adjunctive to standard treatment may improve clinical and functional outcomes in FEP. | es_ES |
dc.description.sponsorship | This study was funded by the Spanish Ministry of Economy and Competitiveness through the Carlos III Health Institute (ISCIII) and the European Regional Development Fund (ERDF) (PI10/01430, PI15/00789, PI18/0155, PI19/00569). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | first-episode psychosis | es_ES |
dc.subject | early intervention | es_ES |
dc.subject | treatment | es_ES |
dc.subject | outcome | es_ES |
dc.subject | randomised controlled trial | es_ES |
dc.title | A Multicentre, Randomised, Controlled Trial of a Combined Clinical Treatment for First-Episode Psychosis | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2021-07-23T13:28:32Z | |
dc.rights.holder | 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/1660-4601/18/14/7239/htm | es_ES |
dc.identifier.doi | 10.3390/ijerph18147239 | |
dc.departamentoes | Neurociencias | |
dc.departamentoes | Personalidad, evaluación y tratamiento psicológico | |
dc.departamentoeu | Neurozientziak | |
dc.departamentoeu | Nortasuna, balioespena eta psikologia tratamendua | |