Nanoflowers versus magnetosomes: comparison between two promising candidates for magnetic hyperthermia therapy
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Date
2021-07-12Author
Jefremovas, Elizabeth M.
Rodrigo Arrizabalaga, Irati
Marcano Prieto, Lourdes
Grüttner, Cordula
García Martínez, José Angel
Garayo Urabayen, Eneko
García Prieto, Ana
Muela Blázquez, Alicia
Fernández Gubieda Ruiz, María Luisa
Alonso, Javier
Fernández Barquín, Luis
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Institute of Electrical and Electronics Engineers 9 : 99552-99561 (2021)
Abstract
[EN] Magnetic Fluid Hyperthermia mediated by iron oxide nanoparticles is one of the most
promising therapies for cancer treatment. Among the different candidates, magnetite and maghemite
nanoparticles have revealed to be some of the most promising candidates due to both their performance and
their biocompatibility. Nonetheless, up to date, the literature comparing the heating ef ciency of magnetite
and maghemite nanoparticles of similar size is scarce. To ll this gap, here we provide a comparison
between commercial Synomag Nano owers (pure maghemite) and bacterial magnetosomes (pure magnetite)
synthesized by the magnetotactic bacterium Magnetospirillum gryphiswaldense of hDi 40 45 nm. Both
types of nanoparticles exhibit a high degree of crystallinity and an excellent degree of chemical purity and
stability. The structural and magnetic properties in both nanoparticle ensembles have been studied by means
of X Ray Diffraction, Transmission Electron Microscopy, X Ray Absorption Spectroscopy, and SQUID
magnetometry. The heating ef ciency has been analyzed in both systems using AC magnetometry at several
eld amplitudes (0 88 mT) and frequencies (130, 300, and 530 kHz).