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Lifestyle-dependent microglial plasticity: training the brain guardians

dc.contributor.authorAugusto-Oliveira, Marcus
dc.contributor.authorVerkhratsky, Alexei
dc.date.accessioned2021-09-24T12:22:31Z
dc.date.available2021-09-24T12:22:31Z
dc.date.issued2021-08-03
dc.identifier.citationBiology Direct 16(1) : (2021) // Article ID 12es_ES
dc.identifier.issn1745-6150
dc.identifier.urihttp://hdl.handle.net/10810/53137
dc.description.abstractLifestyle is one of the most powerful instruments shaping mankind; the lifestyle includes many aspects of interactions with the environment, from nourishment and education to physical activity and quality of sleep. All these factors taken in complex affect neuroplasticity and define brain performance and cognitive longevity. In particular, physical exercise, exposure to enriched environment and dieting act through complex modifications of microglial cells, which change their phenotype and modulate their functional activity thus translating lifestyle events into remodelling of brain homoeostasis and reshaping neural networks ultimately enhancing neuroprotection and cognitive longevity.es_ES
dc.language.isoenges_ES
dc.publisherBMCes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectmicrogliaes_ES
dc.subjectneuroplasticityes_ES
dc.subjectenriched environmentes_ES
dc.subjectphysical exercisees_ES
dc.subjectlifestyle modificationses_ES
dc.subjectdietes_ES
dc.subjectpluslong-term potentiationes_ES
dc.subjecthigh-fat dietes_ES
dc.subjectenvironmental enrichmentes_ES
dc.subjectphysical-activityes_ES
dc.subjecthippocampal neurogenesises_ES
dc.subjectadult neurogenesises_ES
dc.subjectvoluntary exercisees_ES
dc.subjectcognitive functiones_ES
dc.subjectimproves memoryes_ES
dc.subjectdentate gyruses_ES
dc.titleLifestyle-dependent microglial plasticity: training the brain guardianses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holderThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.es_ES
dc.rights.holderAtribución 3.0 España*
dc.relation.publisherversionhttps://www.webofscience.com/wos/alldb/full-record/WOS:000681747300001es_ES
dc.identifier.doi10.1186/s13062-021-00297-4
dc.departamentoesNeurocienciases_ES
dc.departamentoeuNeurozientziakes_ES


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This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Except where otherwise noted, this item's license is described as This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.