Modulation of Conductivity of Alginate Hydrogels Containing Reduced Graphene Oxide through the Addition of Proteins
dc.contributor.author | Raslan, Ahmed | |
dc.contributor.author | Ciriza Astrain, Jesús | |
dc.contributor.author | Ochoa de Retana Mendibil, Ana María | |
dc.contributor.author | Sanjuán, María Luisa | |
dc.contributor.author | Toprak, Muhammet S. | |
dc.contributor.author | Gálvez Martín, Patricia | |
dc.contributor.author | Sáenz del Burgo Martínez, Laura | |
dc.contributor.author | Pedraz Muñoz, José Luis | |
dc.date.accessioned | 2021-09-29T11:00:37Z | |
dc.date.available | 2021-09-29T11:00:37Z | |
dc.date.issued | 2021-09-15 | |
dc.identifier.citation | Pharmaceutics 13(9) : (2021) // Article ID 1473 | es_ES |
dc.identifier.issn | 1999-4923 | |
dc.identifier.uri | http://hdl.handle.net/10810/53169 | |
dc.description.abstract | Modifying hydrogels in order to enhance their conductivity is an exciting field with applications in cardio and neuro-regenerative medicine. Therefore, we have designed hybrid alginate hydrogels containing uncoated and protein-coated reduced graphene oxide (rGO). We specifically studied the adsorption of three different proteins, BSA, elastin, and collagen, and the outcomes when these protein-coated rGO nanocomposites are embedded within the hydrogels. Our results demonstrate that BSA, elastin, and collagen are adsorbed onto the rGO surface, through a non-spontaneous phenomenon that fits Langmuir and pseudo-second-order adsorption models. Protein-coated rGOs are able to preclude further adsorption of erythropoietin, but not insulin. Collagen showed better adsorption capacity than BSA and elastin due to its hydrophobic nature, although requiring more energy. Moreover, collagen-coated rGO hybrid alginate hydrogels showed an enhancement in conductivity, showing that it could be a promising conductive scaffold for regenerative medicine. | es_ES |
dc.description.sponsorship | This study was financially supported by the Basque Country Government [grant number T907-16]. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | |
dc.subject | hydrogel | es_ES |
dc.subject | alginate | es_ES |
dc.subject | reduced graphene oxide | es_ES |
dc.subject | conductivity | es_ES |
dc.subject | collagen | es_ES |
dc.title | Modulation of Conductivity of Alginate Hydrogels Containing Reduced Graphene Oxide through the Addition of Proteins | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2021-09-25T23:33:50Z | |
dc.rights.holder | 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/1999-4923/13/9/1473/htm | es_ES |
dc.identifier.doi | 10.3390/pharmaceutics13091473 | |
dc.departamentoes | Farmacia y ciencias de los alimentos | |
dc.departamentoes | Química orgánica I | |
dc.departamentoeu | Farmazia eta elikagaien zientziak | |
dc.departamentoeu | Kimika organikoa I |
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Except where otherwise noted, this item's license is described as 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).