Hyaluronic acid-based nanoplatforms for Doxorubicin: A review of stimuli-responsive carriers, co-delivery and resistance suppression

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Ikusi/Ireki
Data
2021-11-15
Egilea
Ashrafizadeh, Milad
Mirzaei, Sepideh
Gholami, Mohammad Hossein
Hashemi, Farid
Zabolian, Amirhossein
Raei, Mehdi
Hushmandi, Kiavash
Zarrabi, Ali
Voelcker, Nicolas H.
Aref, Amir Reza
Hamblin, Michael R.
Varma, Rajender S.
Samarghandian, Saeed
Arostegi, I. J.
Alzola, M.
Kumar, Alan Prem
Thakur, Vijay Kumar
Nabavi, Noushin
Makvandi, Pooyan
Tay, Franklin R.
Orive Arroyo, Gorka
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Carbohydrate Polymers 272 : (2021) // Article ID 118491
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http://hdl.handle.net/10810/54418
Laburpena
[EN]An important motivation for the use of nanomaterials and nanoarchitectures in cancer therapy emanates from the widespread emergence of drug resistance. Although doxorubicin (DOX) induces cell cycle arrest and DNA damage by suppressing topoisomerase activity, resistance to DOX has severely restricted its anti-cancer potential. Hyaluronic acid (HA) has been extensively utilized for synthesizing nanoparticles as it interacts with CD44 expressed on the surface of cancer cells. Cancer cells can take up HA-modified nanoparticles through receptor mediated endocytosis. Various types of nanostructures such as carbon nanomaterials, lipid nanoparticles and polymeric nanocarriers have been modified with HA to enhance the delivery of DOX to cancer cells. Hyaluronic acid-based advanced materials provide a platform for the co-delivery of genes and drugs along with DOX to enhance the efficacy of anti-cancer therapy and overcome chemoresistance. In the present review, the potential methods and application of HA-modified nanostructures for DOX delivery in anti-cancer therapy are discussed.
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© 2021 The Author(s). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Bestelakorik adierazi ezean, itemaren baimena horrela deskribatzen da:© 2021 The Author(s). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)