Delta(9)-Tetrahydrocannabinol promotes functional remyelination in the mouse brain
dc.contributor.author | Aguado, Tania | |
dc.contributor.author | Huerga Gómez, Alba | |
dc.contributor.author | Sánchez de la Torre, Aníbal | |
dc.contributor.author | Resel, Eva | |
dc.contributor.author | Chara Ventura, Juan Carlos | |
dc.contributor.author | Matute Almau, Carlos José | |
dc.contributor.author | Mato Santos, Susana | |
dc.contributor.author | Galve-Roperh, Ismael | |
dc.contributor.author | Guzmán, Manuel | |
dc.contributor.author | Palazuelos, Javier | |
dc.date.accessioned | 2022-01-07T11:01:25Z | |
dc.date.available | 2022-01-07T11:01:25Z | |
dc.date.issued | 2021-10 | |
dc.identifier.citation | British Journal of Pharmacology 178(20) : 4176-4192 (2021) | es_ES |
dc.identifier.issn | 0007-1188 | |
dc.identifier.issn | 1476-5381 | |
dc.identifier.uri | http://hdl.handle.net/10810/54833 | |
dc.description.abstract | Background and purpose Research on demyelinating disorders aims to find novel molecules that are able to induce oligodendrocyte precursor cell differentiation to promote central nervous system remyelination and functional recovery. Delta(9)-Tetrahydrocannabinol (THC), the most prominent active constituent of the hemp plant Cannabis sativa, confers neuroprotection in animal models of demyelination. However, the possible effect of THC on myelin repair has never been studied. Experimental approach By using oligodendroglia-specific reporter mouse lines in combination with two models of toxin-induced demyelination, we analysed the effect of THC on the processes of oligodendrocyte regeneration and functional remyelination. Key results We show that THC administration enhanced oligodendrocyte regeneration, white matter remyelination and motor function recovery. THC also promoted axonal remyelination in organotypic cerebellar cultures. THC remyelinating action relied on the induction of oligodendrocyte precursor differentiation upon cell cycle exit and via CB1 cannabinoid receptor activation. Conclusions and implications Overall, our study identifies THC administration as a promising pharmacological strategy aimed to promote functional CNS remyelination in demyelinating disorders. | es_ES |
dc.description.sponsorship | Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, Grant/Award Numbers: CB06/0005/0076, CB06/05/0005; Comunidad de Madrid, Grant/Award Numbers: 2016-T1/BMD-1060, 20205A/BMD-19728; Basque Government (Eusko Jaurlaritza), Grant/Award Numbers: IT1203-19, PIBA19-0059; Fondation pour l'Aide a la Recherche sur la Sclerose en Plaques, ARSEP Foundation; Fundacion Tatiana Perez de Guzman el Bueno; FEDER and Instituto de Salud Carlos III, Grant/Award Numbers: PI18-00941, PI18/00513; Ministerio de Economia y Competitividad, Grant/Award Numbers: PID2020-112640RB-I00, RTI2018095311-B-I00, SAF2016-75292-R, SAF2017-83516 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/PID2020-112640RB-I00 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/RTI2018095311-B-I00 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/SAF2016-75292-R | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/SAF2017-83516 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | cannabinoids | es_ES |
dc.subject | CB1 cannabinoid | es_ES |
dc.subject | receptor | es_ES |
dc.subject | demyelinating disorders | es_ES |
dc.subject | mTORC(1) | es_ES |
dc.subject | oligodendrocyte precursor cells | es_ES |
dc.subject | remyelination | es_ES |
dc.subject | THC | es_ES |
dc.subject | experimental autoimmune encephalomyelitis | es_ES |
dc.subject | cuprizone-induced demyelination | es_ES |
dc.subject | progressive multiple-sclerosis | es_ES |
dc.subject | oligodendrocyte lineage cells | es_ES |
dc.subject | cannabinoid receptors | es_ES |
dc.subject | CNS | es_ES |
dc.subject | model | es_ES |
dc.subject | myelin | es_ES |
dc.subject | cannabidiol | es_ES |
dc.subject | suppression | es_ES |
dc.title | Delta(9)-Tetrahydrocannabinol promotes functional remyelination in the mouse brain | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in anymedium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.© 2021 The Authors.British Journal of Pharmacologypublished by John Wiley & Sons Ltd on behalf of British Pharmacological Society. | es_ES |
dc.rights.holder | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.relation.publisherversion | https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15608 | es_ES |
dc.identifier.doi | 10.1111/bph.15608 | |
dc.departamentoes | Neurociencias | es_ES |
dc.departamentoeu | Neurozientziak | es_ES |
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Except where otherwise noted, this item's license is described as This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in anymedium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.© 2021 The Authors.British Journal of Pharmacologypublished by John Wiley & Sons Ltd on behalf of British Pharmacological Society.