BackImplication of Ceramide Kinase/C1P in Cancer Development and Progression
| dc.contributor.author | Camacho Soguero, Laura | |
| dc.contributor.author | Ouro Villasante, Alberto | |
| dc.contributor.author | Gómez Larrauri, Ana | |
| dc.contributor.author | Carracedo Pérez, Arkaitz  | |
| dc.contributor.author | Gómez Muñoz, Antonio | |
| dc.date.accessioned | 2022-01-13T09:12:16Z | |
| dc.date.available | 2022-01-13T09:12:16Z | |
| dc.date.issued | 2022-01-04 | |
| dc.identifier.citation | Cancers 14(1) : (2022) // Article ID 227 | es_ES |
| dc.identifier.issn | 2072-6694 | |
| dc.identifier.uri | http://hdl.handle.net/10810/54930 | |
| dc.description.abstract | Cancer cells rewire their metabolic programs to favor biological processes that promote cell survival, proliferation, and dissemination. Among this relevant reprogramming, sphingolipid metabolism provides metabolites that can favor or oppose these hallmarks of cancer. The sphingolipid ceramide 1-phosphate (C1P) and the enzyme responsible for its biosynthesis, ceramide kinase (CERK), are well established regulators of cell growth and survival in normal, as well as malignant cells through stress-regulated signaling pathways. This metabolite also promotes cell survival, which has been associated with the feedback regulation of other antitumoral sphingolipids or second messengers. C1P also regulates cancer cell invasion and migration of different types of cancer, including lung, breast, pancreas, prostate, or leukemia cells. More recently, CERK and C1P have been implicated in the control of inflammatory responses. The present review provides an updated view on the important role of CERK/C1P in the regulation of cancer cell growth, survival, and dissemination | es_ES |
| dc.description.sponsorship | Work in AGM lab is supported by ‘Departamento de Educación, Universidades e Investigación del Gobierno Vasco’, Basque Country, Spain (Grant IT1106-16). The work of A. Carracedo is supported by the Basque Department of Industry, Tourism and Trade (Elkartek), the Department of Education (IKERTALDE IT1106-16) and Health (RIS3), the MICINN (PID2019-108787RB-I00 (FEDER/EU), Severo Ochoa Excellence Accreditation SEV-2016-0644, Excellence Networks RED2018-102769-T), the AECC (GCTRA18006CARR), La Caixa Foundation (ID 100010434), under the agreement LCF/PR/HR17/, and the European Research Council (Consolidator Grant 819242). CIBERONC was co-funded with FEDER funds and funded by ISCIII. | es_ES |
| dc.language.iso | eng | es_ES |
| dc.publisher | MDPI | es_ES |
| dc.relation | info:eu-repo/grantAgreement/MICINN/PID2019-108787RB-I00 | es_ES |
| dc.rights | info:eu-repo/semantics/openAccess | es_ES |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | |
| dc.subject | ceramide kinase | es_ES |
| dc.subject | ceramide-1-phosphate | es_ES |
| dc.subject | cancer cell signaling | es_ES |
| dc.subject | tumor cell proliferation | es_ES |
| dc.subject | invasion and dissemination | es_ES |
| dc.title | Implication of Ceramide Kinase/C1P in Cancer Development and Progression | es_ES |
| dc.type | info:eu-repo/semantics/article | es_ES |
| dc.date.updated | 2022-01-10T14:37:51Z | |
| dc.rights.holder | 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | es_ES |
| dc.relation.publisherversion | https://www.mdpi.com/2072-6694/14/1/227/htm | es_ES |
| dc.identifier.doi | 10.3390/cancers14010227 | |
| dc.departamentoes | Bioquímica y biología molecular | |
| dc.departamentoeu | Biokimika eta biologia molekularra |
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Except where otherwise noted, this item's license is described as 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).