dc.contributor.author | Lanuza, José | |
dc.contributor.author | Postils, Verònica | |
dc.contributor.author | López Pestaña, José Javier | |
dc.date.accessioned | 2022-01-14T09:05:07Z | |
dc.date.available | 2022-01-14T09:05:07Z | |
dc.date.issued | 2022-02-01 | |
dc.identifier.citation | Free Radical Biology and Medicine 179 : 200-207 (2022) | es_ES |
dc.identifier.issn | 1873-4596 | |
dc.identifier.uri | http://hdl.handle.net/10810/54984 | |
dc.description.abstract | [EN] The increased bioavailability of aluminum has led to a concern about its toxicity on living systems. Among the most important toxic effects, it has been proven that aluminum increases oxidative stress in biological systems, a controversial fact, however, due to its non-redox nature. In the present work, we characterize in detail how aluminum can alter redox equilibriums by analyzing its effects on the thermodynamics of the redox scavenging reaction between DPPH., a radical compound often used as a reactive oxygen species model, and hydroquinones, a potent natural antioxidant. For the first time, theoretical and experimental redox potentials within aluminum biochemistry are directly compared. Our results fully agree with experimental reduction and oxidation potentials, unequivocally revealing how aluminum alters the spontaneity of the reaction by stabilizing the reduction of DPPH to DPPH- and promoting a proton transfer to the diazine moiety, leading to the production of a DPPH-H species. The capability of aluminum to modify redox potentials shown here confirms previous experimental findings on the role of aluminum to interfere with free radical scavenging reactions, affecting the natural redox processes of living organisms. | es_ES |
dc.description.sponsorship | This research was financially supported by Eusko Jaurlaritza (the Basque Government), through Consolidated Group Project No. IT1254-19, and the Spanish MINECO/FEDER Project No. PGC2018- 097 529-B-100. JL thanks Donostia International Physics center (DIPC) for his Ph.D. grant. VP also thanks Euskal Herriko Unibertsitatea (UPV/EHU) for the PIC 216/18 contract and the ESPDOC18/85 post-doctoral grant. Technical and human support provided by IZO-SGI, SGIker (UPV/EHU, MICINN, GV/EJ and DIPC) is gratefully acknowledged. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PGC2018- 097 529-B-100 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | reactive oxygen species | es_ES |
dc.subject | metal | es_ES |
dc.subject | aluminum | es_ES |
dc.subject | oxidative stress | es_ES |
dc.title | Can aluminum, a non-redox metal, alter the thermodynamics of key biological redox processes? The DPPH-QH2 radical scavenging reaction as a test case | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2021 The Authors. This is an open access article under the CC BY-NC-ND license | es_ES |
dc.rights.holder | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0891584921011606?via%3Dihub | es_ES |
dc.identifier.doi | 10.1016/j.freeradbiomed.2021.12.308 | |
dc.departamentoes | Polímeros y Materiales Avanzados: Física, Química y Tecnología | es_ES |
dc.departamentoeu | Polimero eta Material Aurreratuak: Fisika, Kimika eta Teknologia | es_ES |