The Quantification of IgG Specific to α-Gal Could Be Used as a Risk Marker for Suffering Mammalian Meat Allergy
dc.contributor.author | Joral, Alejandro | |
dc.contributor.author | Azketa, Nahikari | |
dc.contributor.author | Sánchez Hernández, Patricia | |
dc.contributor.author | Vélez del Burgo del Hoyo, Ainara | |
dc.contributor.author | Aranzabal Soto, María Ascensión | |
dc.contributor.author | Lizarza, Susana | |
dc.contributor.author | Martínez Quesada, Jorge | |
dc.contributor.author | Postigo Resa, Idoya | |
dc.date.accessioned | 2022-02-14T15:26:11Z | |
dc.date.available | 2022-02-14T15:26:11Z | |
dc.date.issued | 2022-02-04 | |
dc.identifier.citation | Foods 11(3) : (2022) // Article ID 466 | es_ES |
dc.identifier.issn | 2304-8158 | |
dc.identifier.uri | http://hdl.handle.net/10810/55483 | |
dc.description.abstract | The alpha-Gal Syndrome is a delayed meat allergy characterized by the presence of sIgE against α-Gal epitope. It is known that the α-Gal present in tick saliva induces the sensitization to this epitope ending in the production of sIgG and sIgE to α-Gal. It could be considered that the more times a person is bitten by tick species, the higher the probability of making the switch from sIgG to sIgE to α-Gal and developing allergy, but it is no clear when the switch occurs. To determine the likelihood that a subject bitten by ticks but without AGS be at risk of developing this allergy, we quantified the levels of sIgG to α-Gal by an automated system (ImmunoCap). To stablish a cut-off value for sIgG to α-Gal, a receiving operating curve (ROC) was constructed. The statistical analysis demonstrated that the risk of suffering AGS in individuals bitten by ticks was 35% when the sIgG to α-Gal was greater than or equal to 40 µg/mL. Our data indicate that the sIgG values against α-Gal could be used as a prognostic marker for developing mammalian meat allergy. | es_ES |
dc.description.sponsorship | This research was funded by the Sociedad Española de Alergología e Inmunología Clínica (SEAIC2014) and, by the Department of Education of the Basque Government Grants to support the activities of research groups in the Basque University System (Project IT-1043-16). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | |
dc.subject | α-Gal | es_ES |
dc.subject | food allergy | es_ES |
dc.subject | red meat allergy | es_ES |
dc.subject | tick | es_ES |
dc.subject | sIgG | es_ES |
dc.subject | sIgE | es_ES |
dc.title | The Quantification of IgG Specific to α-Gal Could Be Used as a Risk Marker for Suffering Mammalian Meat Allergy | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2022-02-11T14:46:33Z | |
dc.rights.holder | © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/2304-8158/11/3/466 | es_ES |
dc.identifier.doi | 10.3390/foods11030466 | |
dc.departamentoes | Inmunología, microbiología y parasitología | |
dc.departamentoeu | Immunologia, mikrobiologia eta parasitologia |
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Except where otherwise noted, this item's license is described as © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).