Testicular Germ Cell Tumours and Proprotein Convertases
dc.contributor.author | Velado Egusquiza, Aitziber | |
dc.contributor.author | Gómez Santos, Laura ![]() | |
dc.contributor.author | Badiola Echaburu, Iker ![]() | |
dc.contributor.author | Sáez Crespo, Francisco José ![]() | |
dc.contributor.author | Alonso Arana, Edurne ![]() | |
dc.date.accessioned | 2022-04-20T11:26:35Z | |
dc.date.available | 2022-04-20T11:26:35Z | |
dc.date.issued | 2022-03-23 | |
dc.identifier.citation | Cancers 14(7) : (2022) // Article ID 1633 | es_ES |
dc.identifier.issn | 2072-6694 | |
dc.identifier.uri | http://hdl.handle.net/10810/56369 | |
dc.description.abstract | Testicular Germ Cell Tumours (TGCT) are widely considered a “curable cancer” due to their exceptionally high survival rate, even if it is reduced by many years after the diagnosis due to metastases and relapses. The most common therapeutic approach to TGCTs has not changed in the last 50 years despite its multiple long-term side effects, and because it is the most common malignancy in young Caucasian men, much research is needed to better the quality of life of the many survivors. Proprotein Convertases (PC) are nine serine proteases responsible for the maturation of inactive proproteins with many diverse functions. Alterations in their expression have been associated with various diseases, including cancer and inflammation. Many of their substrates are adhesion molecules, metalloproteases and proinflammatory molecules, all of which are involved in tumour development. Inhibition of certain convertases has also been shown to slow tumour formation, demonstrating their involvement in this process. Considering the very established link between PCs and inflammation-related malignancies and the recent studies carried out into the immune microenvironment of TGCTs, the study of the involvement of PCs in testicular cancer may open up avenues for being both a biomarker for diagnosis and a therapeutic target. | es_ES |
dc.description.sponsorship | This research was funded by the University of the Basque Country UPV/EHU grant number GIU 20/050. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | |
dc.subject | testicular cancer | es_ES |
dc.subject | Testicular Germ Cell Tumours (TGCT) | es_ES |
dc.subject | seminoma | es_ES |
dc.subject | spermatogenesis | es_ES |
dc.subject | Proprotein Convertases (PCs) | es_ES |
dc.title | Testicular Germ Cell Tumours and Proprotein Convertases | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2022-04-11T13:59:17Z | |
dc.rights.holder | 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/2072-6694/14/7/1633/htm | es_ES |
dc.identifier.doi | 10.3390/cancers14071633 | |
dc.departamentoes | Biología celular e histología | |
dc.departamentoeu | Zelulen biologia eta histologia |
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Except where otherwise noted, this item's license is described as 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).