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dc.contributor.authorAndrade del Olmo, Jon
dc.contributor.authorPérez-Álvarez, Leyre
dc.contributor.authorSáez Martínez, Virginia
dc.contributor.authorBenito Cid, Sandra
dc.contributor.authorPérez González, Raúl
dc.contributor.authorVilas Vilela, José Luis ORCID
dc.contributor.authorAlonso, José María
dc.date.accessioned2022-04-28T12:24:54Z
dc.date.available2022-04-28T12:24:54Z
dc.date.issued2022-04-06
dc.identifier.citationGels 8(4) : (2022) // Article ID 223es_ES
dc.identifier.issn2310-286
dc.identifier.urihttp://hdl.handle.net/10810/56415
dc.description.abstractHyaluronic acid (HA) injectable biomaterials are currently applied in numerous biomedical areas, beyond their use as dermal fillers. However, bacterial infections and painful inflammations are associated with healthcare complications that can appear after injection, restricting their applicability. Fortunately, HA injectable hydrogels can also serve as drug delivery platforms for the controlled release of bioactive agents with a critical role in the control of certain diseases. Accordingly, herein, HA hydrogels were crosslinked with 1 4-butanediol diglycidyl ether (BDDE) loaded with cefuroxime (CFX), tetracycline (TCN), and amoxicillin (AMX) antibiotics and acetylsalicylic acid (ASA) anti-inflammatory agent in order to promote antibacterial and anti-inflammatory responses. The hydrogels were thoroughly characterized and a clear correlation between the crosslinking grade and the hydrogels’ physicochemical properties was found after rheology, scanning electron microscopy (SEM), thermogravimetry (TGA), and differential scanning calorimetry (DSC) analyses. The biological safety of the hydrogels, expected due to the lack of BDDE residues observed in 1H-NMR spectroscopy, was also corroborated by an exhaustive biocompatibility test. As expected, the in vitro antibacterial and anti-inflammatory activity of the drug-loaded HA-BDDE hydrogels was confirmed against Staphylococcus aureus by significantly decreasing the pro-inflammatory cytokine levels.es_ES
dc.description.sponsorshipThis research was funded by the i+Med S. Coop., Basque Government (FRONTIERS project, ELKARTEK program, HAZITEK program: IMABI exp number ZE-2019/00012), and the Department of Development and Infrastructures of the Basque Country. Jon Andrade del Olmo thanks the Basque Government for the “Program of Industrial Doctorates. Bikaintek 2018” (exp. number 01-AF-W2-2018-00002).es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/
dc.subjecthyaluronic acides_ES
dc.subjectinjectable hydrogelses_ES
dc.subjectbiocompatibilityes_ES
dc.subjectdrug deliveryes_ES
dc.subjectantibacteriales_ES
dc.subjectanti-inflammatoryes_ES
dc.titleDrug Delivery from Hyaluronic Acid-BDDE Injectable Hydrogels for Antibacterial and Anti-Inflammatory Applicationses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.date.updated2022-04-21T21:04:02Z
dc.rights.holder2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).es_ES
dc.relation.publisherversionhttps://www.mdpi.com/2310-2861/8/4/223/htmes_ES
dc.identifier.doi10.3390/gels8040223
dc.departamentoesQuímica física
dc.departamentoeuKimika fisikoa


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2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Excepto si se señala otra cosa, la licencia del ítem se describe como 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).