Postantifungal Effect of Antifungal Drugs against Candida: What Do We Know and How Can We Apply This Knowledge in the Clinical Setting?
dc.contributor.author | Jauregizar Albonigamayor, Nerea | |
dc.contributor.author | Quindós Andrés, Guillermo | |
dc.contributor.author | Gil-Alonso, Sandra | |
dc.contributor.author | Suárez González, María Elena | |
dc.contributor.author | Sevillano, Elena | |
dc.contributor.author | Eraso, Elena | |
dc.date.accessioned | 2022-08-08T07:13:51Z | |
dc.date.available | 2022-08-08T07:13:51Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Journal of Fungi 8(7) : (2022) // Article ID 727 | es_ES |
dc.identifier.issn | 2309-608X | |
dc.identifier.uri | http://hdl.handle.net/10810/57236 | |
dc.description.abstract | The study of the pharmacological properties of an antifungal agent integrates the drug pharmacokinetics, the fungal growth inhibition, the fungicidal effect and the postantifungal activity, laying the basis to guide optimal dosing regimen selection. The current manuscript reviews concepts regarding the postantifungal effect (PAFE) of the main classes of drugs used to treat Candida infections or candidiasis. The existence of PAFE and its magnitude are highly dependent on both the fungal species and the class of the antifungal agent. Therefore, the aim of this article was to compile the information described in the literature concerning the PAFE of polyenes, azoles and echinocandins against the Candida species of medical interest. In addition, the mechanisms involved in these phenomena, methods of study, and finally, the clinical applicability of these studies relating to the design of dosing regimens were reviewed and discussed. Additionally, different factors that could determine the variability in the PAFE were described. Most PAFE studies were conducted in vitro, and a scarcity of PAFE studies in animal models was observed. It can be stated that the echinocandins cause the most prolonged PAFE, followed by polyenes and azoles. In the case of the triazoles, it is worth noting the inconsistency found between in vitro and in vivo studies | es_ES |
dc.description.sponsorship | The research group was funded by the Consejería de Educación, Universidades e Investigación of Gobierno Vasco-Eusko Jaurlaritza (GIC15/78 IT-990-16/IT1607-22) and by the Spanish Ministry of Science and Innovation (PID2020-117983RB-I00). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2020-117983RB-I00 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | postantifungal effect | es_ES |
dc.subject | antifungal therapy | es_ES |
dc.subject | candidiasis | es_ES |
dc.subject | polyenes | es_ES |
dc.subject | azoles | es_ES |
dc.subject | echinocandins | es_ES |
dc.subject | 5-fluorocytosine | es_ES |
dc.subject | dosing regimen | es_ES |
dc.title | Postantifungal Effect of Antifungal Drugs against Candida: What Do We Know and How Can We Apply This Knowledge in the Clinical Setting? | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2022-07-25T16:33:04Z | |
dc.rights.holder | © 2022 by the authors.Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/2309-608X/8/7/727 | es_ES |
dc.identifier.doi | 10.3390/jof8070727 | |
dc.departamentoes | Inmunología, microbiología y parasitología | |
dc.departamentoes | Farmacología | |
dc.departamentoeu | Immunologia, mikrobiologia eta parasitologia | |
dc.departamentoeu | Farmakologia |
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Except where otherwise noted, this item's license is described as © 2022 by the authors.Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).