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Asymmetric Michael Addition in Synthesis of β-Substituted GABA Derivatives

dc.contributor.authorHan, Jianlin ORCID
dc.contributor.authorEscorihuela, Jorge
dc.contributor.authorFustero, Santos ORCID
dc.contributor.authorLanda Alvarez, Aitor
dc.contributor.authorSoloshonok, Vadym Anatolievch ORCID
dc.contributor.authorSorochinsky, Alexander ORCID
dc.date.accessioned2022-08-09T08:44:57Z
dc.date.available2022-08-09T08:44:57Z
dc.date.issued2022
dc.identifier.citationMolecules 27(12) : (2022) // Article ID 3797es_ES
dc.identifier.issn1420-3049
dc.identifier.urihttp://hdl.handle.net/10810/57260
dc.description.abstractγ-Aminobutyric acid (GABA) represents one of the most prolific structural units widely used in the design of modern pharmaceuticals. For example, β-substituted GABA derivatives are found in numerous neurological drugs, such as baclofen, phenibut, tolibut, pregabalin, phenylpiracetam, brivaracetam, and rolipram, to mention just a few. In this review, we critically discuss the literature data reported on the preparation of substituted GABA derivatives using the Michael addition reaction as a key synthetic transformation. Special attention is paid to asymmetric methods featuring synthetically useful stereochemical outcomes and operational simplicity.es_ES
dc.description.sponsorshipThis research was funded by the National Natural Science Foundation of China (No. 21761132021), and IKERBASQUE, Basque Foundation for Science. The financial support from the University of the Basque Country UPV/EHU (UFIQOSYC11/22), Basque Government (GVgrant IT1236-19), and Ministerio de Ciencia e Innovación (grant PID2019-109633GBC21) for. A.L. are also acknowledged.es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relationinfo:eu-repo/grantAgreement/MICINN/PID2019-109633GBC21es_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectpharmaceuticalses_ES
dc.subjectneurological drugses_ES
dc.subjectγ-aminobutyric-acid derivativeses_ES
dc.subjectasymmetric Michael additiones_ES
dc.subjectchiral auxiliarieses_ES
dc.subjectenantioselective organocatalysises_ES
dc.titleAsymmetric Michael Addition in Synthesis of β-Substituted GABA Derivativeses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.date.updated2022-06-23T12:22:15Z
dc.rights.holder© 2022 by the authors.Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).es_ES
dc.relation.publisherversionhttps://www.mdpi.com/1420-3049/27/12/3797es_ES
dc.identifier.doi10.3390/molecules27123797
dc.departamentoesQuímica orgánica I
dc.departamentoeuKimika organikoa I


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© 2022 by the authors.Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
Except where otherwise noted, this item's license is described as © 2022 by the authors.Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).