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Development of Geometry-Controlled All-Orthogonal BODIPY Trimers for Photodynamic Therapy and Phototheragnosis

dc.contributor.authorPrieto Castañeda, Alejandro
dc.contributor.authorGarcía Garrido, Fernando
dc.contributor.authorDíaz Norambuena, Carolina
dc.contributor.authorEscriche Navarro, Blanca
dc.contributor.authorGarcía Fernández, Alba
dc.contributor.authorBañuelos Prieto, Jorge ORCID
dc.contributor.authorRebollar, Esther ORCID
dc.contributor.authorGarcía Moreno, Inmaculada
dc.contributor.authorMartínez Máñez, Ramón
dc.contributor.authorde la Moya, Santiago
dc.contributor.authorAgarrabeitia, Antonia R.
dc.contributor.authorOrtiz, María J.
dc.date.accessioned2022-09-02T09:02:00Z
dc.date.available2022-09-02T09:02:00Z
dc.date.issued2022-05
dc.identifier.citationOrganic Letters 24(20) : 3636-3641 (2022)es_ES
dc.identifier.issn1523-7060
dc.identifier.issn1523-7052
dc.identifier.urihttp://hdl.handle.net/10810/57419
dc.description.abstractWe have established an easy synthetic protocol for selectively developing all-orthogonal BODIPY trimers with unprece-dented geometries on the basis of selecting methyl oxidation versus electrophilic formylation of key dimeric precursors. Photophysical characterization together with biological assays unraveled the most suitable BODIPY-BODIPY geometrical arrangements within the trimer, forcing them to serve as molecular platforms for the development of new, advanced heavy-atom-free photosensitizers for photodynamic therapy and phototheragnosis.es_ES
dc.description.sponsorshipThe authors acknowledge Spanish MICINN (PID2020-11455GB-C31, -C32, and -C33 and RTI2018-100910-BC41), Spanish Instituto de Salud Carlos III (IFI19/00026), Gobierno Vasco (IT1639-22), and Generalitat Valenciana (PROMETEO 2018/024) for financial support. A.P.-C. thanks Comunidad de Madrid for a research contract. C.D.-N. thanks MICINN for a FPI contract. B.E.-N. thanks the IFI19/00026 project, which is co-funded by the European Union, for a research contract.es_ES
dc.language.isoenges_ES
dc.publisherAmerican Chemical Societyes_ES
dc.relationinfo:eu-repo/grantAgreement/MICIU/RTI2018-100910-BC41es_ES
dc.relationinfo:eu-repo/grantAgreement/MICINN/PID2020-11455GB-C31es_ES
dc.relationinfo:eu-repo/grantAgreement/MICINN/PID2020-11455GB-C32es_ES
dc.relationinfo:eu-repo/grantAgreement/MICINN/PID2020-11455GB-C33es_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectrational designes_ES
dc.subjectphotosensitizerses_ES
dc.subjectdimerses_ES
dc.titleDevelopment of Geometry-Controlled All-Orthogonal BODIPY Trimers for Photodynamic Therapy and Phototheragnosises_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holder© 2022 The Authors. Published by American Chemical Society. Attribution 4.0 International (CC BY 4.0)es_ES
dc.rights.holderAtribución 3.0 España*
dc.relation.publisherversionhttps://pubs.acs.org/doi/10.1021/acs.orglett.2c01169es_ES
dc.identifier.doi10.1021/acs.orglett.2c01169
dc.departamentoesQuímica físicaes_ES
dc.departamentoeuKimika fisikoaes_ES


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© 2022 The Authors. Published by American Chemical Society. Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as © 2022 The Authors. Published by American Chemical Society. Attribution 4.0 International (CC BY 4.0)