Heart-brain synchronization breakdown in Parkinson's disease
dc.contributor.author | Iñiguez, Martín | |
dc.contributor.author | Jiménez Marín, Antonio | |
dc.contributor.author | Erramuzpe Aliaga, Asier | |
dc.contributor.author | Acera, Marian | |
dc.contributor.author | Tijero Merino, Beatriz | |
dc.contributor.author | Murueta-Goyena Larrañaga, Ane | |
dc.contributor.author | Del Pino Sáez, Rocío | |
dc.contributor.author | Fernández Valle, Tamara | |
dc.contributor.author | Carmona Abellán, Mar | |
dc.contributor.author | Cabrera Zubizarreta, Alberto | |
dc.contributor.author | Gómez Esteban, Juan Carlos | |
dc.contributor.author | Cortés Díaz, Jesús María | |
dc.contributor.author | Gabilondo Cuellar, Iñigo | |
dc.date.accessioned | 2022-09-02T09:02:27Z | |
dc.date.available | 2022-09-02T09:02:27Z | |
dc.date.issued | 2022-05 | |
dc.identifier.citation | NPJ Parkinson's Desease 8 : (2022) // Article ID 64 | es_ES |
dc.identifier.issn | 2373-8057 | |
dc.identifier.uri | http://hdl.handle.net/10810/57421 | |
dc.description.abstract | Heart rate variability (HRV) abnormalities are potential early biomarkers in Parkinson's disease (PD) but their relationship with central autonomic network (CAN) activity is not fully understood. We analyzed the synchronization between HRV and brain activity in 31 PD patients and 21 age-matched healthy controls using blood-oxygen-level-dependent (BOLD) signals from resting-state functional brain MRI and HRV metrics from finger plethysmography recorded for 7.40 min. We additionally quantified autonomic symptoms (SCOPA-AUT) and objective autonomic cardiovascular parameters (blood pressure and heart rate) during deep breathing, Valsalva, and head-up tilt, which were used to classify the clinical severity of dysautonomia. We evaluated HRV and BOLD signals synchronization (HRV-BOLD-sync) with Pearson lagged cross-correlations and Fisher's statistics for combining window-length-dependent HRV-BOLD-Sync Maps and assessed their association with clinical dysautonomia. HRV-BOLD-sync was lower significantly in PD than in controls in various brain regions within CAN or in networks involved in autonomic modulation. Moreover, heart-brain synchronization index (HBSI), which quantifies heart-brain synchronization at a single-subject level, showed an inverse exposure-response relationship with dysautonomia severity, finding the lowest HBSI in patients with severe dysautonomia, followed by moderate, mild, and, lastly, controls. Importantly, HBSI was associated in PD, but not in controls, with Valsalva pressure recovery time (sympathetic), deep breathing E/I ratio (cardiovagal), and SCOPA-AUT. Our findings support the existence of heart-brain de-synchronization in PD with an impact on clinically relevant autonomic outcomes. | es_ES |
dc.description.sponsorship | We want to thank all the patients and participants involved in the study. This study was partially co-funded by Michael J. Fox Foundation [RRIA 2014 (Rapid Response Innovation Awards) Program (Grant ID: 10189)], by the Carlos III Health Institute, and the European Union (ERDF/ESF, "A Way to Make Europe"/"Investing in Your Future") through the projects PI14/00679 and PI16/00005, the Juan Rodes grant "JR15/00008" (I.G.), and by the Department of Health of the Basque Government through the project "2016111009" and "2020333033". A.J.M. was supported by a predoctoral grant from the Basque Government (PRE_2019_1_0070). M.I. acknowledges financial support from"La Caixa" Foundation (ID 100010434, fellowship LCF/BQ/EU20/11810065). The Edmond and Lily Safra Center for Brain Sciences and the Basque Government (POS_2019_2_0020) to A.E. J.M.C. is funded by Ikerbasque: The Basque Foundation for Science and from the Ministerial de Economia, Industria y Competitividad (Spain) and FEDER (grant DPI2016-79874-R), and from the Department of Economic and Infrastructure Development of the Basque Country (Elkartek Program, KK-2018/00032, KK-2018/00090, and KK-2021/00009/BCB). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | mibg myocardial scintigraphy | es_ES |
dc.subject | rate variability | es_ES |
dc.subject | autonomic dysfunction | es_ES |
dc.subject | orthostatic hypotension | es_ES |
dc.subject | poincare plot | es_ES |
dc.subject | system | es_ES |
dc.subject | dysautonomia | es_ES |
dc.subject | cerebellum | es_ES |
dc.subject | network | es_ES |
dc.subject | connectivity | es_ES |
dc.title | Heart-brain synchronization breakdown in Parkinson's disease | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.nature.com/articles/s41531-022-00323-w | es_ES |
dc.identifier.doi | 10.1038/s41531-022-00323-w | |
dc.departamentoes | Neurociencias | es_ES |
dc.departamentoeu | Neurozientziak | es_ES |
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