Ru-Catalyzed C-H Hydroxylation of Tyrosine-Containing Di- and Tripeptides toward the Assembly of L-DOPA Derivatives
dc.contributor.author | Andrade Sampedro, Paula | |
dc.contributor.author | Matxain Beraza, Jon Mattin | |
dc.contributor.author | Correa Navarro, Arkaitz | |
dc.date.accessioned | 2022-09-08T08:39:46Z | |
dc.date.available | 2022-09-08T08:39:46Z | |
dc.date.issued | 2022-06-21 | |
dc.identifier.citation | Advanced Synthesis & Catalysis 364(12) : 2072-2079 (2022) | es_ES |
dc.identifier.issn | 1615-4150 | |
dc.identifier.issn | 1615-4169 | |
dc.identifier.uri | http://hdl.handle.net/10810/57483 | |
dc.description.abstract | [EN] The development of catalytic tools for the late-stage modification of amino acids within a peptide framework is a challenging task of capital importance. Herein, we report a Ru-catalyzed C(sp(2))-H hydroxylation of a collection of Tyr-containing di- and tripeptides featuring the use of a carbamate as a removable directing group and PhI(OCOCF3)(2) (PIFA) as oxidant. This air-compatible tagging technique is reliable, scalable and provides access to L-DOPA (L-3,4-dihydroxyphenylalanine) peptidomimetics in a racemization-free fashion. Density Functional Theory calculations support a Ru(II)/Ru(IV) catalytic cycle. | es_ES |
dc.description.sponsorship | We are grateful to Ministerio de Ciencia e Innovacion (RTI2018-093721-B-I00, MCI/AEI/FEDER, UE) and Basque Government (IT1033-16 and IT1254-19) for financial support. We thank for technical and human support provided by SGIker of UPV/EHU and European funding (ERDF and ESF). P. A.-S. thanks DIPC for the research contract. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICIU/RTI2018-093721-B-I00 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | hydroxylation | es_ES |
dc.subject | tyrosine | es_ES |
dc.subject | ruthenium catalysis | es_ES |
dc.subject | peptides | es_ES |
dc.subject | C-H functionalization | es_ES |
dc.title | Ru-Catalyzed C-H Hydroxylation of Tyrosine-Containing Di- and Tripeptides toward the Assembly of L-DOPA Derivatives | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2022 The Authors. Advanced Synthesis & Catalysis published by Wiley-VCHGmbH. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial No Derivs License,which permits use and distributionin any medium,provided the origina lwork is properly cited, the use is non-commercial and no modifications or adaptations are made. | es_ES |
dc.rights.holder | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/10.1002/adsc.202200234 | es_ES |
dc.identifier.doi | 10.1002/adsc.202200234 | |
dc.departamentoes | Polímeros y Materiales Avanzados: Física, Química y Tecnología | es_ES |
dc.departamentoes | Química orgánica I | es_ES |
dc.departamentoeu | Polimero eta Material Aurreratuak: Fisika, Kimika eta Teknologia | es_ES |
dc.departamentoeu | Kimika organikoa I | es_ES |
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Except where otherwise noted, this item's license is described as © 2022 The Authors. Advanced Synthesis & Catalysis published by Wiley-VCHGmbH. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial No Derivs License,which permits use and distributionin any medium,provided the origina lwork is properly cited, the use is non-commercial and no modifications or adaptations are made.