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Examining the variability of neurocognitive functioning in individuals at clinical high risk for psychosis: a meta-analysis
dc.contributor.author | Catalán Alcántara, Ana | |
dc.contributor.author | Radua, Joaquim | |
dc.contributor.author | McCutcheon, Robert | |
dc.contributor.author | Aymerich, Claudia | |
dc.contributor.author | Pedruzo, Borja | |
dc.contributor.author | González Torres, Miguel Ángel | |
dc.contributor.author | Baldwin, Helen | |
dc.contributor.author | Stone, William S. | |
dc.contributor.author | Giuliano, Anthony J. | |
dc.contributor.author | McGuire, Philip | |
dc.contributor.author | Fusar-Poli, Paolo | |
dc.date.accessioned | 2022-09-08T11:43:05Z | |
dc.date.available | 2022-09-08T11:43:05Z | |
dc.date.issued | 2022-05-12 | |
dc.identifier.citation | Translational Psychiatry 12 : (2022) // Article ID 198 | es_ES |
dc.identifier.issn | 2158-3188 | |
dc.identifier.uri | http://hdl.handle.net/10810/57662 | |
dc.description.abstract | This study aims to meta-analytically characterize the presence and magnitude of within-group variability across neurocognitive functioning in young people at Clinical High-Risk for psychosis (CHR-P) and comparison groups. Multistep, PRISMA/MOOSE-compliant systematic review (PROSPERO-CRD42020192826) of the Web of Science database, Cochrane Central Register of Reviews and Ovid/PsycINFO and trial registries up to July 1, 2020. The risk of bias was assessed using a modified version of the NOS for cohort and cross-sectional studies. Original studies reporting neurocognitive functioning in individuals at CHR-P compared to healthy controls (HC) or first-episode psychosis (FEP) patients were included. The primary outcome was the random-effect meta-analytic variability ratios (VR). Secondary outcomes included the coefficient of variation ratios (CVR). Seventy-eight studies were included, relating to 5162 CHR-P individuals, 2865 HC and 486 FEP. The CHR-P group demonstrated higher variability compared to HC (in descending order of magnitude) in visual memory (VR: 1.41, 95% CI 1.02-1.94), executive functioning (VR: 1.31, 95% CI 1.18-1.45), verbal learning (VR: 1.29, 95% CI 1.15-1.45), premorbid IQ (VR: 1.27, 95% CI 1.09-1.49), processing speed (VR: 1.26, 95% CI 1.07-1.48), visual learning (VR: 1.20, 95% CI 1.07-1.34), and reasoning and problem solving (VR: 1.17, 95% CI 1.03-1.34). In the CVR analyses the variability in CHR-P population remains in the previous neurocognitive domains and emerged in attention/vigilance, working memory, social cognition, and visuospatial ability. The CHR-P group transitioning to psychosis showed greater VR in executive functioning compared to those not developing psychosis and compared to FEP groups. Clinical high risk for psychosis subjects shows increased variability in neurocognitive performance compared to HC. The main limitation of this study is the validity of the VR and CVR as an index of variability which has received debate. This finding should be explored by further individual-participant data research and support precision medicine approaches. | es_ES |
dc.description.sponsorship | This research received funding from the OSI Bilbao Basurto Research Commission. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Springer | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | 1st-episode psychosis | es_ES |
dc.subject | schizophrenia | es_ES |
dc.subject | heterogeneity | es_ES |
dc.subject | performance | es_ES |
dc.subject | predictors | es_ES |
dc.subject | capacity | es_ES |
dc.subject | deficits | es_ES |
dc.subject | recognition | es_ES |
dc.subject | transition | es_ES |
dc.subject | conversion | es_ES |
dc.title | Examining the variability of neurocognitive functioning in individuals at clinical high risk for psychosis: a meta-analysis | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.nature.com/articles/s41398-022-01961-7#rightslink | es_ES |
dc.identifier.doi | 10.1038/s41398-022-01961-7 | |
dc.departamentoes | Neurociencias | es_ES |
dc.departamentoeu | Neurozientziak | es_ES |
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Bestelakorik adierazi ezean, itemaren baimena horrela deskribatzen da:This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.