The Palma Echo Platform: Rationale and Design of an Echocardiography Core Lab
dc.contributor.author | López Rodríguez, Luis | |
dc.contributor.author | Rossello, Xabier | |
dc.contributor.author | Romaguera, Dora | |
dc.contributor.author | Alonso Gómez, Ángel María | |
dc.contributor.author | Toledo, Estefanía | |
dc.contributor.author | Fortuny Frau, Elena | |
dc.contributor.author | Noris, Marta | |
dc.contributor.author | Mas Lladó, Caterina | |
dc.contributor.author | Fiol, Miquel | |
dc.contributor.author | Ramallal, Raúl | |
dc.contributor.author | Tojal Sierra, Lucas | |
dc.contributor.author | Alonso, Álvaro | |
dc.contributor.author | Fernández Palomeque, Carlos | |
dc.date.accessioned | 2022-09-28T16:23:53Z | |
dc.date.available | 2022-09-28T16:23:53Z | |
dc.date.issued | 2022-06 | |
dc.identifier.citation | Frontiers in Cardiovascular Medicine 9 : (2022) // Article ID 909347 | es_ES |
dc.identifier.issn | 2297-055X | |
dc.identifier.uri | http://hdl.handle.net/10810/57862 | |
dc.description.abstract | Background: The metabolic syndrome (MetS) is associated with increased cardiovascular morbidity and mortality. Characterization of cardiac structural and functional abnormalities due to the MetS can help recognize individuals who would benefit the most from preventive interventions. Transthoracic echocardiography (TTE) provides an opportunity to identify those abnormalities in a reproducible and cost-efficient manner. In research settings, implementation of protocols for the acquisition and analysis of TTE images are key to ensure validity and reproducibility, thus facilitating answering relevant questions about the association of the MetS with cardiac alterations. Methods and Results: The Palma Echo Platform (PEP) is a coordinated network that is built up to evaluate the underlying structural and functional cardiac substrate of participants with MetS. Repeated TTE will be used to evaluate 5-year changes in the cardiac structure and function in a group of 565 individuals participating in a randomized trial of a lifestyle intervention for the primary prevention of cardiovascular disease. The echocardiographic studies will be performed at three study sites, and will be centrally evaluated at the PEP core laboratory. Planned analyses will involve evaluating the effect of the lifestyle intervention on cardiac structure and function, and the association of the MetS and its components with changes in cardiac structure and function. Particular emphasis will be placed on evaluating parameters of left atrial structure and function, which have received more limited attention in past investigations. This PEP will be available for future studies addressing comparable questions. Conclusion: In this article we describe the protocol of a central echocardiography laboratory for the study of functional and structural alterations of the MetS. | es_ES |
dc.description.sponsorship | Research reported in this publication was supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health under Award Numbers R01HL137338 and K24HL148521, and administrative supplement to promote diversity 3R01HL137338-03S1. This work was supported by the official Spanish Institutions for funding scientific biomedical research, CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN) and Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigación para la Salud (FIS), which was co-funded by the European Regional Development Fund (PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332, PI20/01802, PI20/00138, PI20/01532, PI20/00456, PI20/00339, PI20/00557, PI20/00886, and PI20/01158); the Especial Action Project entitled: Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-Plus; the European Research Council (Advanced Research Grant 2014–2019; agreement #340918); the Recercaixa (number 2013ACUP00194); grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013, PS0358/2016, PI0137/2018); the PROMETEO/2017/017 grant from the Generalitat Valenciana; the SEMERGEN grant; none of the funding sources took part in the design, collection, analysis, interpretation of the data, or writing the report, or in the decision to submit the manuscript for publication. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Frontiers Media | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/340918 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | echocardiagraphy | es_ES |
dc.subject | core laboratory | es_ES |
dc.subject | randomized clinical trial | es_ES |
dc.subject | metabolic syndrome | es_ES |
dc.subject | atrial fibrillation | es_ES |
dc.subject | atrial function | es_ES |
dc.title | The Palma Echo Platform: Rationale and Design of an Echocardiography Core Lab | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2022 López, Rossello, Romaguera, Alonso-Gómez, Toledo, Fortuny, Noris, Mas-Lladó, Fiol, Ramallal, Tojal-Sierra, Alonso and Fernandez-Palomeque. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.frontiersin.org/articles/10.3389/fcvm.2022.909347/full | es_ES |
dc.identifier.doi | 10.3389/fcvm.2022.909347 | |
dc.contributor.funder | European Commission | |
dc.departamentoes | Medicina | es_ES |
dc.departamentoeu | Medikuntza | es_ES |
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