Anxiety, depression, health-related quality of life, and mortality among colorectal patients: 5-year follow-up

Orive Calzada, Miren; Antón Ladislao, Ane; Lázaro Aramburu, Santiago; González, Nerea; Baré Mañas, Marisa; Fernández de Larrea, Nerea; Redondo, Maximino; Bilbao, Amaia; Sarasqueta Eizaguirre, Cristina; Aguirre, Urko; Quintana López, José María; REDISSEC-CARESS CCR Group

dc.contributor.author	Orive Calzada, Miren
dc.contributor.author	Antón Ladislao, Ane
dc.contributor.author	Lázaro Aramburu, Santiago
dc.contributor.author	González, Nerea
dc.contributor.author	Baré Mañas, Marisa
dc.contributor.author	Fernández de Larrea, Nerea
dc.contributor.author	Redondo, Maximino
dc.contributor.author	Bilbao, Amaia
dc.contributor.author	Sarasqueta Eizaguirre, Cristina
dc.contributor.author	Aguirre, Urko
dc.contributor.author	Quintana López, José María
dc.contributor.author	REDISSEC-CARESS CCR Group
dc.date.accessioned	2022-10-21T15:14:27Z
dc.date.available	2022-10-21T15:14:27Z
dc.date.issued	2022
dc.identifier.citation	Supportive Care in Cancer 30 : 7943-7954 (2022)	es_ES
dc.identifier.issn	0941-4355
dc.identifier.issn	1433-7339
dc.identifier.uri	http://hdl.handle.net/10810/58155
dc.description.abstract	Purpose Health-related quality of life (HRQoL) measurement represents an important outcome in cancer patients. We describe the evolution of HRQoL over a 5-year period in colorectal cancer patients, identifying predictors of change and how they relate to mortality. Methods Prospective observational cohort study including colorectal cancer (CRC) patients having undergone surgery in nineteen public hospitals who were monitored from their diagnosis, intervention and at 1-, 2-, 3-, and 5-year periods thereafter by gathering HRQoL data using the EuroQol-5D-5L (EQ-5D-5L), European Organization for Research and Treatment of Cancer's Quality of Life Questionnaire-Core 30 (EORTC-QLQ-C30), and Hospital Anxiety and Depression Scale (HADS) questionnaires. Multivariable generalized linear mixed models were used. Results Predictors of Euroqol-5D-5L (EQ-5D-5L) changes were having worse baseline HRQoL; being female; higher Charlson index score (more comorbidities); complications during admission and 1 month after surgery; having a stoma after surgery; and needing or being in receipt of social support at baseline. For EORTC-QLQ-C30, predictors of changes were worse baseline EORTC-QLQ-C30 score; being female; higher Charlson score; complications during admission and 1 month after admission; receiving adjuvant chemotherapy; and having a family history of CRC. Predictors of changes in HADS anxiety were being female and having received adjuvant chemotherapy. Greater depression was associated with greater baseline depression; being female; higher Charlson score; having complications 1 month after intervention; and having a stoma. A deterioration in all HRQoL questionnaires in the previous year was related to death in the following year. Conclusions These findings should enable preventive follow-up programs to be established for such patients in order to reduce their psychological distress and improve their HRQoL to as great an extent as possible.	es_ES
dc.description.sponsorship	Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This work was supported in part by grants from the Instituto de Salud Carlos III and the European Regional Development Fund (PS09/00314, PS09/00910, PS09/00746, PS09/00805, PI09/90460, PI09/90490, PI09/90453, PI09/90441, PI09/90397); the Departments of Health (2010111098) and Education, Language Policy and Culture (IT620-13) of the Basque Government; the Research Committee of Hospital Galdakao; and the thematic network-REDISSEC (Red de Investigacion en Servicios de Salud en Enfermedades Cronicas)-of the Instituto de Salud Carlos III.	es_ES
dc.language.iso	eng	es_ES
dc.publisher	Springer	es_ES
dc.rights	info:eu-repo/semantics/openAccess	es_ES
dc.rights.uri	http://creativecommons.org/licenses/by/3.0/es/	*
dc.subject	colorectal cancer	es_ES
dc.subject	patient-reported outcome measures	es_ES
dc.subject	health-related quality of life	es_ES
dc.subject	cohort studies	es_ES
dc.subject	longitudinal studies	es_ES
dc.title	Anxiety, depression, health-related quality of life, and mortality among colorectal patients: 5-year follow-up	es_ES
dc.type	info:eu-repo/semantics/article	es_ES
dc.rights.holder	© The Author(s) 2022. This article is licensed under a Creative Commons Attri- bution 4.0 International License, which permits use, sharing, adapta- tion, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.	es_ES
dc.rights.holder	Atribución 3.0 España	*
dc.relation.publisherversion	https://link.springer.com/article/10.1007/s00520-022-07177-1	es_ES
dc.identifier.doi	10.1007/s00520-022-07177-1
dc.departamentoes	Psicología Social	es_ES
dc.departamentoeu	Gizarte Psikologia	es_ES

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© The Author(s) 2022. This article is licensed under a Creative Commons Attri-
bution 4.0 International License, which permits use, sharing, adapta-
tion, distribution and reproduction in any medium or format, as long
as you give appropriate credit to the original author(s) and the source,
provide a link to the Creative Commons licence, and indicate if changes
were made. The images or other third party material in this article are
included in the article's Creative Commons licence, unless indicated
otherwise in a credit line to the material. If material is not included in
the article's Creative Commons licence and your intended use is not
permitted by statutory regulation or exceeds the permitted use, you will
need to obtain permission directly from the copyright holder. To view a
copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Except where otherwise noted, this item's license is described as © The Author(s) 2022. This article is licensed under a Creative Commons Attri- bution 4.0 International License, which permits use, sharing, adapta- tion, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.